Journal ArticleDOI
The role of sialic acid in determining the life-span of circulating cells and glycoproteins
TLDR
The role of sialic acid in determining the life of circulating cells and glycoproteins is reviewed and an attempt is made to assess its real importance and to interpret the desialylation pathway.Abstract:
The role of sialic acid in determining the life of circulating cells and glycoproteins is reviewed and an attempt is made to assess its real importance and to interpret the desialylation pathway. An overall view of factors, including desialylated glycoprotein fragments, that may regulate hepatic synthesis of glycoproteins is presented.read more
Citations
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Macrophages and Metastasis—A Biological Approach to Cancer Therapy: Presidential Address
Journal ArticleDOI
In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes.
A J Schroit,J W Madsen,Y. Tanaka +2 more
TL;DR: It is shown that 51Cr-labeled RBC containing NBD-PS-containing RBC are rapidly cleared from the peripheral circulation of syngeneic mice and accumulate in the liver and spleen and suggest that the exposure of endogenous PS in the outer leaflet of RBC which occurs in certain pathological conditions could trigger their removal from the circulation.
Journal ArticleDOI
Glycopeptide changes and malignant transformation a possible role for cabohydrate in malignant behavior
Journal ArticleDOI
Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration.
TL;DR: The results indicate that the rate of in vivo metabolism of TBG is dependent on its sialic acid content and the more heavily sialylated anodal bands of purified but unfractionated serum TBG survived longer in the circulation of a rat.
Journal ArticleDOI
Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages
Y Tanaka,A J Schroit +1 more
TL;DR: It is suggested that PS in the outer leaflet of RBC might serve as a signal for triggering their recognition by macrophages.
References
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Journal ArticleDOI
The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.
Book ChapterDOI
The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.
Gilbert Ashwell,Anatol G. Morell +1 more
Journal ArticleDOI
The Role of Sialic Acid in Determining the Survival of Glycoproteins in the Circulation
TL;DR: Evidence is presented to indicate a generalized role for the terminal sialic acid residues of circulating glycoproteins of desialylated plasma proteins inducers of gonadotropic hormones and follicle-stimulating hormone.
Journal ArticleDOI
The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins.
Roger L. Hudgin,Roger L. Hudgin,W.E. Pricer,W.E. Pricer,Gilbert Ashwell,Gilbert Ashwell,Richard J. Stockert,Richard J. Stockert,A G Morell,A G Morell +9 more
TL;DR: The purification, by affinity chromatography, of an hepatic protein which retains the characteristic binding properties associated with the membranes is described, which indicates a high degree of aggregation in the final, water-soluble preparation.
Journal ArticleDOI
Physical and Chemical Studies on Ceruloplasmin: V. METABOLIC STUDIES ON SIALIC ACID-FREE CERULOPLASMIN IN VIVO
A G Morell,A G Morell,R A Irvine,R A Irvine,I Sternlieb,I Sternlieb,I.H. Scheinberg,I.H. Scheinberg,Gilbert Ashwell,Gilbert Ashwell +9 more
TL;DR: Injection into rabbits of radioactive ceruloplasmin from which sialic acid had been removed enzymatically resulted in a rapid disappearance of the asialoceruloplAsmin from the serum and its appearance in parenchymal cells, but not in Kupffer cells, of the liver.