Journal ArticleDOI
The simple β-carboline alkaloids
James R.F. Allen,Bo Holmstedt +1 more
TLDR
The simple β-carbolines are presented as a distinct group of alkaloids displaying structural modification of three basic ring systems and aspects of their metabolism, pharmacological properties and taxonomic significance are briefly summarized.About:
This article is published in Phytochemistry.The article was published on 1980-01-01. It has received 253 citations till now.read more
Citations
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Journal ArticleDOI
Formation of tetrahydro-β-carbolines in human saliva
TL;DR: The results indicate that both precursors, tryptamine and aldehydes, coexist in oral environments and that their interaction to form TBC and MTBC potentially occurs in human saliva without participation of salivary enzyme.
Journal ArticleDOI
Sequential one-pot five-component synthesis of tetrazole-based spirotetrahydro-β-carbolines
TL;DR: A one-pot five-component two-step sequential synthesis of tetrazole-based tetrahydrospiro[indene-2,1′-pyrido[3,4-b]indole]-1,3-diones in moderate to good yields is described.
Journal ArticleDOI
Nitrogen-containing compounds from the moss Fontinalis squamosa
TL;DR: In this article, the alkaloid harmol and its hitherto unknown propionic acid derivative as well as a new amino acid derivative fontinalin were isolated from the watermoss Fontinalis squamosa.
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Urinary excretion of the enantiomers of 1-methyl-1,2,3,4-tetrahydro-β-carboline in unequal abundance implies enzymatic metabolism in man
H Tsuchiya,H Todoriki,T Hayashi +2 more
TL;DR: The stereoselective difference in the urinary excretion of 1-methyl-1,2,3,4-tetrahydro-β-carboline administered exogenously implies that it is enzymatically metabolized, but not that its biosynthesis is associated with an enzymatic reaction.
References
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Journal ArticleDOI
Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds
TL;DR: Harmaline and related compounds have been shown to be potent inhibitors of monoamine oxidase effecting 50 per cent inhibition of serotonin metabolism at 10−6 M.
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Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke
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“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
L. Rivier,Jan-Erik Lindgren +1 more
TL;DR: Harmine, Harmaline, Tetrahydroharmine and Dimethyltryptamine have been found in the Ayahuasca drink.
Journal ArticleDOI
The isolation of harmane and norharmane from tobacco and cigarette smoke
E.H. Poindexter,R.D. Carpenter +1 more
TL;DR: Harmane and norharmane were isolated from cured tobacco and its smoke and the addition of radioactive tryptophan to the tobacco resulted in the isolation of radioactive harmane alkaloids in the smoke, establishing the presence of indole alkaloid in tobacco.
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Interactions of norharman and harman with DNA
TL;DR: Agarose gel electrophoresis of circular DNA, closed in the presence or absence of norharman revealed that the dye intercalates DNA, thereby causing 17 +/- 3 degrees unwinding of the double helix.