Journal ArticleDOI
The simple β-carboline alkaloids
James R.F. Allen,Bo Holmstedt +1 more
TLDR
The simple β-carbolines are presented as a distinct group of alkaloids displaying structural modification of three basic ring systems and aspects of their metabolism, pharmacological properties and taxonomic significance are briefly summarized.About:
This article is published in Phytochemistry.The article was published on 1980-01-01. It has received 253 citations till now.read more
Citations
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Journal ArticleDOI
KI‐assisted Sulfur Activation/Insertion/Denitration Strategy towards Dual C−S Bond Formation for One‐pot Synthesis of β‐Carboline‐tethered 2‐Acylbenzothiophenes
TL;DR: In this paper , a simple and efficient KI promoted sulfur activation-insertion/de-nitration strategy has been developed for the synthesis of β-carboline C1 tethered 2-acylbenzothiophenes via one-pot assembly of 1-acetyl β-carbolines (an alkaloid based scaffold), 2-nirobenzaldehydes and elemental sulfur.
Journal ArticleDOI
Catalyst‐Free Site‐Selective Diverse Functionalization of Inherent C–H Bonds in 1‐Aryl‐β‐carbolines, Norharmane and Harmine
TL;DR: In this paper , a site-selective additive-free functionalization of latent C−H bonds in 1-aryl-β-carbolines and natural norharmane and harmine has been accomplished.
Journal ArticleDOI
Tetrahydro-β-carboline-naphthalimide hybrids: Synthesis and anti-proliferative evaluation on estrogen-dependent and triple-negative breast cancer cells
Shalini,Shubham Lata,Sourav Taru Saha,Mandeep Kaur,Paul Awolade,Oluwakemi Ebenezer,Parvesh Singh,Vipan Kumar Vipan Kumar +7 more
TL;DR: In this article , a series of tetrahydro-β-carboline-naphthalimide hybrids were designed and synthesized via an amide coupling reaction, and the obtained hybrids were evaluated for their growth inhibitory potential against MCF7 and MDA-MB-231 breast cancer cell lines using MTT assay.
Book ChapterDOI
Effects of Cyanobacterial Metabolites on Other Bacterial Phyla and in the Morphogenesis, Viability, and Biochemistry of Eukaryotes
T. G. Villa,L. Feijoo,Sandra Sánchez,J. L. R. Rama,Angeles Sánchez-Pérez,T. de Migel,Carmen Sieiro +6 more
TL;DR: Recently, a large increase in the number of completed cyanobacterial genomes has been reported as discussed by the authors, which promises many interesting discoveries in the near future, with broad mechanisms of action, many of which are probably yet unknown.
References
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Journal ArticleDOI
Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds
TL;DR: Harmaline and related compounds have been shown to be potent inhibitors of monoamine oxidase effecting 50 per cent inhibition of serotonin metabolism at 10−6 M.
Journal ArticleDOI
Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke
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“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
L. Rivier,Jan-Erik Lindgren +1 more
TL;DR: Harmine, Harmaline, Tetrahydroharmine and Dimethyltryptamine have been found in the Ayahuasca drink.
Journal ArticleDOI
The isolation of harmane and norharmane from tobacco and cigarette smoke
E.H. Poindexter,R.D. Carpenter +1 more
TL;DR: Harmane and norharmane were isolated from cured tobacco and its smoke and the addition of radioactive tryptophan to the tobacco resulted in the isolation of radioactive harmane alkaloids in the smoke, establishing the presence of indole alkaloid in tobacco.
Journal ArticleDOI
Interactions of norharman and harman with DNA
TL;DR: Agarose gel electrophoresis of circular DNA, closed in the presence or absence of norharman revealed that the dye intercalates DNA, thereby causing 17 +/- 3 degrees unwinding of the double helix.