Journal ArticleDOI
The simple β-carboline alkaloids
James R.F. Allen,Bo Holmstedt +1 more
TLDR
The simple β-carbolines are presented as a distinct group of alkaloids displaying structural modification of three basic ring systems and aspects of their metabolism, pharmacological properties and taxonomic significance are briefly summarized.About:
This article is published in Phytochemistry.The article was published on 1980-01-01. It has received 253 citations till now.read more
Citations
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Tansley Review No. 43 Light-activated plant defence
TL;DR: The role of light in photosynthesis and photomorphogenesis has been appreciated for some time, but the role ofLight in plant defence is a comparatively recent realization.
Journal ArticleDOI
Photophysics of norharmane in solution phase: from homogeneous to microheterogeneous environments
TL;DR: The photobehavior of norharmane (9H-pyrido[3,4-b]-indole) (NHM), one of the vastly used skeleton of drugs in therapeutic applications, has recently been the subject of increasing interest due to the finding of their phototoxic and photocarcinogenic properties.
Patent
1-substituted 1,2,3,4-tetrahydro-beta-carboline and 3,4-dihydro-beta-carboline and analogs as antitumor agents
Sheau Farn Yeh,Ya-Ching Shen +1 more
TL;DR: In this paper, a composition of a substituted dihydro- or tetrahydro-β-carboline of formula (II) or (III) is defined, where the aromatic ring of the carboline may include one or more substituents selected from the group consisting of hydroxy, C 1-6 alkoxy, benzyloxy, acyloxy and carboxy.
Journal ArticleDOI
Acid–base and spectral properties of β-carbolines. Part 1. Tetrahydro-β-carbolines
TL;DR: In this paper, the absorption and fluorescence spectra of a set of tetrahydro-β-carboline derivatives in the HI/pH/H range of −11 to +18 have shown the presence of four different molecular species, namely: dication, cation, neutral and anion.
Journal ArticleDOI
β-Carboline Alkaloids, Part 8.1 Regioselective Homolytic Acetylation of β-Carbolines
F Bracher,J Daab +1 more
TL;DR: In this paper, homolytic acetylation of 3-ethoxycarbonyl-β-carboline and norharmane occurs selectively at 1 position and better yields are obtained by generation of the acetyl radical from acetaldehyde than by oxidative decarboxylating of pyruvic acid.
References
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Journal ArticleDOI
Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds
TL;DR: Harmaline and related compounds have been shown to be potent inhibitors of monoamine oxidase effecting 50 per cent inhibition of serotonin metabolism at 10−6 M.
Journal ArticleDOI
Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke
Journal ArticleDOI
“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
L. Rivier,Jan-Erik Lindgren +1 more
TL;DR: Harmine, Harmaline, Tetrahydroharmine and Dimethyltryptamine have been found in the Ayahuasca drink.
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The isolation of harmane and norharmane from tobacco and cigarette smoke
E.H. Poindexter,R.D. Carpenter +1 more
TL;DR: Harmane and norharmane were isolated from cured tobacco and its smoke and the addition of radioactive tryptophan to the tobacco resulted in the isolation of radioactive harmane alkaloids in the smoke, establishing the presence of indole alkaloid in tobacco.
Journal ArticleDOI
Interactions of norharman and harman with DNA
TL;DR: Agarose gel electrophoresis of circular DNA, closed in the presence or absence of norharman revealed that the dye intercalates DNA, thereby causing 17 +/- 3 degrees unwinding of the double helix.