Journal ArticleDOI
The simple β-carboline alkaloids
James R.F. Allen,Bo Holmstedt +1 more
TLDR
The simple β-carbolines are presented as a distinct group of alkaloids displaying structural modification of three basic ring systems and aspects of their metabolism, pharmacological properties and taxonomic significance are briefly summarized.About:
This article is published in Phytochemistry.The article was published on 1980-01-01. It has received 253 citations till now.read more
Citations
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Flazin, Perlolyrin, and other ß-Carbolines from marine derived Bacteria
Mohamed Shaaban,D. Schröder,Khaled A. Shaaban,Elisabeth Helmke,Iris Grün-Wollny,Irene Wagner-Döbler,H. Laatsch +6 more
TL;DR: FromethylacetateextractsofthemarineStreptomycesspp.
Journal ArticleDOI
A practical oxidative C–H functionalization of N-carbamoyl tetrahydro-β-carbolines with diverse potassium trifluoroborates
Yi Sun,Yi Sun,Gang Wang,Jiayu Chen,Chang Liu,Manqi Cai,Rongxiu Zhu,Haofei Huang,Wei Li,Lei Liu +9 more
TL;DR: This reaction has excellent functional group tolerance, and exhibits a broad range of potassium trifluoroborate components, allowing for the facile C-H functionalization of electronically varied N-carbamoyl THCs in high efficiency with excellent regioselectivity.
Book ChapterDOI
Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System
Carolina dos Santos Passos,Claudia A. Simões-Pires,Amélia T. Henriques,Muriel Cuendet,Pierre-Alain Carrupt,Philippe Christen +5 more
TL;DR: This chapter considers selectivity on MAO isoforms and SAR issues of various classes of alkaloids, mainly related to the serotonergic and glutamatergic transmission of indole alkaloid.
Journal ArticleDOI
High-performance liquid chromatographic analysis of tetrahydro-β-carbolines in food plants
Hironori Tsuchiya,Kuniaki Yamada,Hirotsugu Kato,Hideaki Hayashi,Takashi Miyazaki,Tokishi Hayashi +5 more
TL;DR: In this paper, a liquid chromatographic method was proposed for the unambiguous determination of the amount of tetrahydro-β-carbolines in food plants, and the results showed that tomato, banana, pineapple, kiwi, plum and prune contain both 1,2,3,4 and 1,methyl-1,2.3, 4-tetrahedroβ-carboline at ng to μg/g levels.
Journal ArticleDOI
A mild novel synthesis of simple 1-oxo-β-carbolines
Reija Jokela,Mauri Lounasmaa +1 more
TL;DR: In this paper, a new route using very mild reaction conditions is described for the transformation of indoloquinolizidines 4 and 5 to the 1-oxo-1,2,3,4-tetrahydro-β-carbolines 2 and 3
References
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Journal ArticleDOI
Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds
TL;DR: Harmaline and related compounds have been shown to be potent inhibitors of monoamine oxidase effecting 50 per cent inhibition of serotonin metabolism at 10−6 M.
Journal ArticleDOI
Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke
Journal ArticleDOI
“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
L. Rivier,Jan-Erik Lindgren +1 more
TL;DR: Harmine, Harmaline, Tetrahydroharmine and Dimethyltryptamine have been found in the Ayahuasca drink.
Journal ArticleDOI
The isolation of harmane and norharmane from tobacco and cigarette smoke
E.H. Poindexter,R.D. Carpenter +1 more
TL;DR: Harmane and norharmane were isolated from cured tobacco and its smoke and the addition of radioactive tryptophan to the tobacco resulted in the isolation of radioactive harmane alkaloids in the smoke, establishing the presence of indole alkaloid in tobacco.
Journal ArticleDOI
Interactions of norharman and harman with DNA
TL;DR: Agarose gel electrophoresis of circular DNA, closed in the presence or absence of norharman revealed that the dye intercalates DNA, thereby causing 17 +/- 3 degrees unwinding of the double helix.