Journal ArticleDOI
The size of a pilot study for a clinical trial should be calculated in relation to considerations of precision and efficiency.
Julius Sim,Martyn Lewis +1 more
TLDR
Trialists should calculate the appropriate size of a pilot study, just as they should the size of the main RCT, taking into account the twin needs to demonstrate efficiency in terms of recruitment and to produce precise estimates of treatment effect.About:
This article is published in Journal of Clinical Epidemiology.The article was published on 2012-03-01. It has received 524 citations till now. The article focuses on the topics: Sample size determination & Confidence interval.read more
Citations
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Journal ArticleDOI
Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable
TL;DR: This paper looks at how to choose an external pilot trial sample size in order to minimise the sample size of the overall clinical trial programme, that is, the pilot and the main trial together, and produces a method of calculating the optimal solution.
Journal ArticleDOI
An audit of sample sizes for pilot and feasibility trials being undertaken in the United Kingdom registered in the United Kingdom Clinical Research Network database
TL;DR: The target sample sizes set for pilot and feasibility randomised controlled trials, currently running within the United Kingdom, are described to describe the observed sample sizes in feasibility and pilot randomisedcontrolled trials on the UKCRN Database.
Journal ArticleDOI
Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study.
TL;DR: This work uses a simulation approach to illustrate the sampling distribution of the standard deviation for continuous outcomes and the event rate for binary outcomes, and presents the impact of increasing the pilot sample size on the precision and bias of these estimates, and predicted power under three realistic scenarios.
Journal ArticleDOI
Peer-Delivered Recovery Support Services for Addictions in the United States: A Systematic Review
TL;DR: This systematic review identifies, appraises, and summarizes the evidence on the effectiveness of peer-delivered recovery support services for people in recovery from alcohol and drug addiction.
Journal ArticleDOI
A simple formula for the calculation of sample size in pilot studies
Wolfgang Viechtbauer,Luc J.M. Smits,Daniel Kotz,Luc Budé,Mark Spigt,Jan Serroyen,Rik Crutzen +6 more
TL;DR: A simple formula is presented to calculate the sample size needed to be able to identify, with a chosen level of confidence, problems that may arise with a given probability.
References
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Book
Statistical Power Analysis for the Behavioral Sciences
TL;DR: The concepts of power analysis are discussed in this paper, where Chi-square Tests for Goodness of Fit and Contingency Tables, t-Test for Means, and Sign Test are used.
Journal ArticleDOI
Design and analysis of pilot studies: recommendations for good practice
TL;DR: A well-conducted pilot study, giving a clear list of aims and objectives within a formal framework will encourage methodological rigour, ensure that the work is scientifically valid and publishable, and will lead to higher quality RCTs.
Journal ArticleDOI
Sample size of 12 per group rule of thumb for a pilot study
TL;DR: When designing a clinical trial an appropriate justification for the sample size should be provided in the protocol, but there are a number of settings when undertaking a pilot trial when there is no prior information to base a sample size on.
Book
Statistics with confidence
TL;DR: Uncertainty and Psychological Research Variables and Measurement Exploring, Describing, Displaying and Summarizing Research Design and Probability Sampling Distributions and Confidence Intervals Statistical Models and Significance Tests Predicting a Quantitative Variable from a Categorical Variable The t Test and Analysis of Variance Quantitative Predictors Regression and Correlation Predicting categorical Variables Contingency Tables and Chi-square More than Two Variables A Peek at Multivariate Analysis Putting Statistics into Perspective
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SPIRIT 2013 statement: defining standard protocol items for clinical trials.
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