Journal ArticleDOI
The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review
TLDR
The structure characteristics related with bactericide actions, including peptides constituents, molecular length, molecular charges and so on are reviewed, and the common mode of actions of AMPs raised by researchers are summarized.Abstract:
Background The rapid increase of drug resistance in conventional antibiotics promotes the discovery and development of antimicrobial peptides (AMPs), which are important components of natural immunity. Due to the specific action modes targeting for cell membrane, AMPs have become a promising substance for bacterium inhibitions barely with no drug resistance. Here we reviewed the structure characteristics related with bactericide actions, including peptides constituents, molecular length, molecular charges and so on. And we also summarized the common mode of actions of AMPs raised by researchers. The structure-mechanism relationship was discussed. The commonly used methods for mechanism study were also listed. Key findings and conclusions The structures of AMPs were strongly related with its efficacy, such as constituents, molecular length, charges, secondary structures. The main mechanisms of AMPs were divided into membrane targets and intracellular targets. Some advanced and new techniques were applied in the mechanism study. Most of the existed mechanisms are still suppositional, and techniques were mainly focused on membrane-associated mechanism, only few of them were related with intracellular factors. Therefore, more new methods are expected to explore the authentic mechanisms and better results as well as more intracellular targets. This review provides a reference for future AMPs chemical modification and mechanism exploration.read more
Citations
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Antimicrobial peptides and their application in food packaging
TL;DR: In this article, the authors describe AMPs and their use in the food packaging industry along with their characteristics, functions, properties, types, and mechanisms of action in active food packaging systems.
Journal ArticleDOI
Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability.
TL;DR: In this article , the progress made in improving the proteolytic stability of AMPs and the principle, successes, and limitations of various anti-proteolytic design strategies are discussed.
D-Amino Acids and D-Amino Acid-Containing Peptides: Potential Disease Biomarkers and Therapeutic Targets?
TL;DR: In this paper, the presence of DAACPs and free D-amino acids and their links with disease development and progress are summarized, highlighting some recent advances in analytical techniques that led to improvement in the discovery and analysis of DAMACP and DAMINO acids.
Journal ArticleDOI
Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives
TL;DR: In this article, a review of self-assembling peptide hydrogels with inherent antimicrobial ability has recently come to the fore, and their fundamental antimicrobial properties, selectivity and mechanism of action are relatively undefined.
Journal ArticleDOI
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria.
Cesar Augusto Roque-Borda,Patrícia Bento da Silva,Mosar Corrêa Rodrigues,Leonardo Delello Di Filippo,Jonatas Lobato Duarte,Marlus Chorilli,Eduardo Vicente,Saulo Santesso Garrido,Fernando Rogério Pavan +8 more
TL;DR: In this article , the authors present a review article on different reported nanosystems using AMPs against bacteria listed on the WHO priority list, and the current shortage of information implies a nanobiotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect.
References
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.
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Bacterial biofilm and associated infections
Muhsin Jamal,Wisal Ahmad,Saadia Andleeb,Fazal Jalil,Muhammad Imran,Muhammad Asif Nawaz,Tahir Hussain,Muhammad Faaiq Ali,Muhammad Rafiq,Muhammad Atif Kamil +9 more
TL;DR: Understanding of bacterial biofilm is important to manage and/or to eradicate biofilm-related diseases, utilizing both device-related and non-device-related infections.
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Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action.
TL;DR: In this review, the structures of a number of different Trp- and Arg-rich antimicrobial peptides are examined and some of the major mechanistic studies are presented.
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Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations
TL;DR: Strong membrane-binding and micromolar therapeutic concentrations of AMPs indicate that membrane-bound concentrations may be reached that are higher than intuitively expected, triggering disruptive effects on bacteria.