Journal ArticleDOI
The synthesis and properties of t25 glycoprotein in thy-1- -negative mutant lymphoma cells.
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TLDR
Data indicate that normal glycosylation of T25 glycoprotein is probably essential for the molecule to be incorporated into the plasma membrane and expressed on the cell surface.About:
This article is published in Cell.The article was published on 1978-05-01. It has received 148 citations till now. The article focuses on the topics: Glycoprotein & Glycosylation.read more
Citations
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Journal ArticleDOI
Carbohydrate moieties of glycoproteins a re-evaluation of their function
TL;DR: It is proposed that the carbohydrate acts as a chemical ‘tag’ which, upon interaction with a specific intracellular membrane receptor, directs glycoproteins to specific cellular organelles following synthesis on the rough endoplasmic reticulum.
Journal ArticleDOI
Mammalian microRNAs: a small world for fine-tuning gene expression.
TL;DR: It is argued that developing mouse models for deleted and/or overexpressed microRNAs will be of invaluable interest to decipher the regulatory networks where micro RNAs are involved in mammalian diseases, with particular focus on cancer.
Journal ArticleDOI
Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues
TL;DR: The glycoprotein exists in two antithetical allelic forms and is identical to a polymorphic surface molecule independently characterized by Colombatti and co-workers, and can be detected on lung, kidney, brain, and liver as well as cultured fibroblasts.
Journal ArticleDOI
Biosynthesis of the human transferrin receptor in cultured cells.
M B Omary,Ian S. Trowbridge +1 more
TL;DR: Evidence is presented that the mature receptor contains both complex and high mannose N-asparagine-linked oligosaccharides that are synthesized via a common highMannose intermediate as previously described for other glycoproteins.
Book ChapterDOI
The Function of Saccharide-Lipids in Synthesis of Glycoproteins
Douglas K. Struck,W.J. Lennarz +1 more
TL;DR: As discussed in Chapter 1, one of the major classes of glycoproteins is that in which the carbohydrate chain is linked to the polypeptide chain by means of an N-glycosidic bond.
References
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Journal ArticleDOI
Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
TL;DR: It is demonstrated that pre-exposure of the film to a brief flash of light greatly increases the sensitivity of fluorography, because it corrects the non-linear relationship between radioactivity of the sample and absorbance of theFilm image.
Journal ArticleDOI
The akr thymic antigen and its distribution in leukemias and nervous tissues
Arnold E. Reif,Joan M. Allen +1 more
TL;DR: A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct.
Journal ArticleDOI
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
Jan S. Tkacz,J. Oliver Lampen +1 more
TL;DR: Tunicamycin inhibited the production of the [3H]G1cNAc-lipid but did not affect the synthesis of the 14C-mannolipid, which accounts for the effect of the antibiotic upon glycoprotein formation in vivo.
Journal ArticleDOI
Protein-Carbohydrate Interaction. II. Inhibition Studies on the Interaction of Concanavalin A with Polysaccharides*
Journal ArticleDOI
Comparative Aspects of Glycoprotein Structure
TL;DR: Of all the biologically occurring macromolecules the glycoproteins, which consist of carbohydrate moieties convalently linked to a polypeptide backbone, represent the most diverse group, ranging from substances in which the carbohydrate component represents less than 1% of the total weight to those in which it represents over 80% ofThe total.