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Thiopyrans and Their Benzo Derivatives
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The article was published on 2020-01-01. It has received 1 citations till now. The article focuses on the topics: Ring (chemistry) & Section (typography).read more
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Journal ArticleDOI
Synthesis and Biological Activities of 5-Thio-α-GalCers.
TL;DR: Three new KRN7000 structural analogues were designed and synthesized, in which the ring oxygen of the galactopyranose residue is replaced by a sulfur atom along with the variation on the lipid chain, for stimulating mouse NKT cells to produce IFN-γ and IL-4.
Journal ArticleDOI
Organocatalytic Asymmetric Synthesis of Spiro−tetrahydrothiophene Oxindoles Bearing Four Contiguous Stereocenters by One-Pot Michael-Henry-Cascade-Rearrangement Reactions
Shengzheng Wang,Zhongjie Guo,Shuqiang Chen,Yan Jiang,Fan Zhang,Xueying Liu,Weiping Chen,Chunquan Sheng +7 more
TL;DR: The bottleneck was addressed by an unprecedented one-pot Michael-Henry-cascade-rearrangement reaction that could simultaneously create four consecutive stereogenic centers including two tetrasubstituted carbon stereocenters.
Journal ArticleDOI
Copper/Selectfluor‐System‐Catalyzed Dehydration–Oxidation of Tertiary Cycloalcohols: Access to β‐Substituted Cyclohex‐2‐enones, 4‐Arylcoumarins, and Biaryls
TL;DR: In this article, a one-pot Cu0/Selectfluor-catalyzed dehydration-oxidation of tertiary cycloalcohols was used to obtain β-substituted cyclohex-2-enones, 4-arylcoumarins, and biaryls.
Journal ArticleDOI
N-Heterocyclic Carbene-Catalyzed Intramolecular Nucleophilic Substitution: Enantioselective Construction of All-Carbon Quaternary Stereocenters.
TL;DR: An efficient enantioselective N-heterocyclic carbene (NHC)-catalyzed intramolecular SN 2' nucleophilic substitution of aldehydes with (E/Z)-trisubstituted allylic bromides was accomplished and a range of enantioenriched chromanones bearing an all-carbon quaternary stereocenter at the C3 position were prepared.
Journal ArticleDOI
Activity of sulfonium bisphosphonates on tumor cell lines.
Yonghui Zhang,Michael P. Hudock,Kilannin Krysiak,Rong Cao,Kyle Bergan,Fenglin Yin,and Annette Leon,Eric Oldfield +7 more
TL;DR: Three QSAR models showed that the experimental cell growth inhibition results could be well predicted, and the structures of one sulfonium bisphosphonate bound to farnesyl diphosphate synthase were determined, finding that it binds exclusively to the dimethylallyl diph phosphate binding site.