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Thiopyrans and Their Benzo Derivatives
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The article was published on 2020-01-01. It has received 1 citations till now. The article focuses on the topics: Ring (chemistry) & Section (typography).read more
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Organocatalytic asymmetric sulfa-Michael addition of thiols to 4,4,4-trifluorocrotonates.
TL;DR: The first asymmetric sulfa-Michael addition of thiols to 4,4,4-trifluorocrotonates for the construction of a stereogenic center bearing a unique trifloromethyl group and a sulfur atom has been achieved in high yields and excellent enantioselectivities with a 1 mol % bifunctional organocatalyst.
Journal ArticleDOI
Organocatalytic asymmetric vinylogous addition to quinones – formation of optically active α-aryl ketones
TL;DR: The first organocatalytic addition of dicyanoalkylidenes to quinones catalyzed by Cinchona alkaloids leading to formation of 1,4-diketone derivatives with high diastereomeric ratios and enantioselectivities has been developed.
Journal ArticleDOI
Structurally diverse α-substituted benzopyran synthesis through a practical metal-free C(sp3)-H functionalization.
TL;DR: A metal-free reaction has an excellent functional group tolerance and high chemoselectivity and displays a broad scope with respect to both benzopyran and nucleophile partners, efficiently affording a collection of Benzopyrans bearing diverse skeletons and α-functionalities in one step.
Journal ArticleDOI
A new (S)-prolinamide modified by an ionic liquid moiety—a high performance recoverable catalyst for asymmetric aldol reactions in aqueous media
TL;DR: In this article, new prolinamide derivatives modified with ionic liquid moieties were synthesized and studied as organocatalysts in asymmetric aldol reactions in water.
Journal ArticleDOI
Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis
Patrick R. Baldwin,Analise Z. Reeves,Kimberly R. Powell,Ruth J. Napier,Alyson Swimm,Aiming Sun,Kyle E. Giesler,Bettina Bommarius,Thomas M. Shinnick,James P. Snyder,Dennis C. Liotta,Daniel Kalman +11 more
TL;DR: Data provide a structural basis for the development of analogs of curcumin with pronounced anti-mycobacterial activity and provide a roadmap to develop additional structural analogs that exhibit more favorable interactions with other anti-TB drugs.