Three New Neolignans and One New Phenylpropanoid from the Leaves and Stems of Toona ciliata var. pubescens

TLDR: In this paper, three neolignans, (7S,8S,7′E)-4, 9-dihydroxy-3,7,3′,9′-tetramethoxy-8,4′-oxyneolign-7′-ene, and one new phenylpropanoid, threo-5-hydroxy- 3,7-dimethylthiazol-2-yl)-2,5-diphenyl-2H-Tetrazolium bromide (4), were

Abstract: Three new neolignans, (7S,8S,7′E)-4,9-dihydroxy-3,7,3′,9′-tetramethoxy-8,4′-oxyneolign-7′-ene (1), (7R,8S,7′E)-4, 9-dihydroxy-3,7,3′,9′-tetramethoxy-8,4′-oxyneolign-7′-ene (2), (7S,8S,7′E)-5, 9-dihydroxy-3,7,3′,5′,9′-pentamethoxy-8,4′-oxyneolign-7′-ene (3), and one new phenylpropanoid, threo-5-hydroxy-3,7-dimethoxyphenylpropane-8,9-diol (4), were isolated from the leaves and stems of Toona ciliata var. pubescens. Their structures were determined on the basis of spectroscopic analysis, especially 2D-NMR, HR-ESI-MS, and CD data. The antiproliferative activities of these compounds against four tumor cell lines (A549, Colo 205, QGY-7703, and LOVO) were also evaluated by MTT (=(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method.