TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.
Patricia A. Taylor,Michael J. Ehrhardt,Christopher J. Lees,Angela Panoskaltsis-Mortari,Arthur M. Krieg,Arlene H. Sharpe,William J. Murphy,Jonathan S. Serody,Hiroaki Hemmi,Shizuo Akira,Robert B. Levy,Bruce R. Blazar +11 more
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TLDR
It is shown that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor 9 (TLR9) ligation of host antigen-presenting cells (APCs), dependent upon host IFNgamma but independent of host IL-12, IL-6, or natural killer cells.About:
This article is published in Blood.The article was published on 2008-10-15 and is currently open access. It has received 77 citations till now. The article focuses on the topics: TLR9 & Antigen-presenting cell.read more
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Multipotent mesenchymal stromal cells and the innate immune system
TL;DR: It is important to study the crosstalk between MSCs and innate immunity, which ranges from the bone marrow niche to injured tissue, and to identify components of the innate immune system also have a key role.
Journal ArticleDOI
MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease
Markus M. Heimesaat,Axel Nogai,Stefan Bereswill,Rita Plickert,André Fischer,Christoph Loddenkemper,Ulrich Steinhoff,Sandrine Tchaptchet,Eckhard Thiel,Marina A. Freudenberg,Ulf B. Göbel,Lutz Uharek +11 more
TL;DR: The important role of TLR9-mediated immunopathology was independently confirmed by significantly reduced macroscopic disease symptoms and colonic apoptosis as well as by reduced T-cell and neutrophil numbers within the colon after treatment with a synthetic inhibitory oligonucleotide.
Journal ArticleDOI
New perspectives on the biology of acute GVHD
TL;DR: A novel perspective on the immunobiology of acute GVHD is provided and some of the outstanding questions and limitations of the model systems are discussed.
Journal ArticleDOI
Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors
TL;DR: These insights identify important mechanisms regarding the induction of GVHD through the interplay of microbial molecules and innate immunity, thus opening a new area for future therapeutic approaches.
Journal ArticleDOI
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
Lisa K. Jasperson,Christoph Bucher,Angela Panoskaltsis-Mortari,Andrew L. Mellor,David H. Munn,Bruce R. Blazar +5 more
TL;DR: It is shown that upon arrival in the colon, activated donor T cells produced interferon-gamma that up-regulated IDO, causing T-cell anergy and apoptosis, and it is concluded that IDO up-regulation may have therapeutic potential for preventing GVHD in the clinic.
References
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Journal ArticleDOI
Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
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Cpg motifs in bacterial dna trigger direct b-cell activation
Arthur M. Krieg,Ae-Kyung Yi,Sara Matson,Thomas J. Waldschmidt,Gail A. Bishop,Gail A. Bishop,Rebecca M. Teasdale,Gary A. Koretzky,Dennis M. Klinman +8 more
TL;DR: The potent immune activation by CpG oligon nucleotides has impli-cations for the design and interpretation of studies using 'antisense' oligonucleotides and points to possible new applications as adjuvants.
Journal ArticleDOI
Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
Journal ArticleDOI
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hiroaki Hemmi,Tsuneyasu Kaisho,Osamu Takeuchi,Shintaro Sato,Hideki Sanjo,Katsuaki Hoshino,Takao Horiuchi,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira +9 more
TL;DR: It is shown that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88–dependent signaling pathway, and that neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells.
Journal ArticleDOI
CpG Motifs in Bacterial DNA and Their Immune Effects
TL;DR: Oligodeoxynucleotides containing CpG ODN enhance the development of acquired immune responses for prophylactic and therapeutic vaccination and protect against lethal challenge with a wide variety of pathogens.
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Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
Konrad Wilhelm,Jayanthi Ganesan,Tobias Müller,Christoph Dürr,Melanie Grimm,Andreas Beilhack,Christine D. Krempl,Stephan Sorichter,Ulrike V. Gerlach,Eva Jüttner,Alf Zerweck,Frank Gärtner,Patrizia Pellegatti,Francesco Di Virgilio,Davide Ferrari,Neeraja Kambham,Paul Fisch,Jürgen Finke,Marco Idzko,Robert Zeiser +19 more