Journal ArticleDOI
Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways.
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TLDR
In-depth studies should be continuously performed to identify the ligand specificity of all TLRs in fish, particularly non-mammalian TLRs, and their signaling pathways.About:
This article is published in Fish & Shellfish Immunology.The article was published on 2014-12-01. It has received 237 citations till now. The article focuses on the topics: Toll-like receptor & Pattern recognition receptor.read more
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Journal ArticleDOI
A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish
TL;DR: This review will discuss and compare components of both the innate and adaptive immune systems in Gnathostomes, particularly in Chondrichthyes (cartilaginous fish) and in Osteichthyes [bony fish: the Actinopterygii (ray-finned fish] and the SarcopteryGii (lobe- Finned fish)].
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Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways.
TL;DR: The major PRR signaling pathways in the zebrafish innate immune system are reviewed and compared with humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.
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Polarization of immune responses in fish: The 'macrophages first' point of view.
TL;DR: These cytokines considered most critical to the dichotomous development of TH1/M1 and TH2/M2 polarization, in particular, but not exclusively, interferon-γ and interleukin (IL)-4/IL-13 are summarized.
Journal ArticleDOI
Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)
TL;DR: The mechanistic and structural basis of fish TLR and NLR activation is outlined and its interaction with pathogen associated molecular patterns (PAMPs) and downstream signaling molecules are discussed.
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The effect of partial replacement of fish meal by soy protein concentrate on growth performance, immune responses, gut morphology and intestinal inflammation for juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂).
Junxian Wang,Dazhi Liang,Qihui Yang,Beiping Tan,Xiaohui Dong,Shuyan Chi,Hongyu Liu,Shuang Zhang +7 more
TL;DR: An 8-week feeding trial was conducted to investigate the effects of partial replacement of fish meal by soy protein concentrate (SPC) on the growth performance, immune responses, intestine morphology and relation gene expression of intestinal inflammation for juvenile hybrid grouper.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
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Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
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A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.