Journal ArticleDOI
Topological asymmetry of phospholipids in membranes
LD Bergelson,LI Barsukov +1 more
TLDR
NSF Science Education: Basic Issues Still Unresolved.... as discussed by the authors, GAO Decision on NSF Claim Favors Curriculum Study Group, and NAS and Justice Panels Pan Federal Crime Research Effort.Abstract:
NSF Science Education: Basic Issues Still Unresolved. . . . . . . . . . . . . . . . 233 GAO Decision on NSF Claim Favors Curriculum Study Group . . . . . . . . . . . 234 NAS and Justice Panels Pan Federal Crime Research Effort .... . . . . . . . . 236 Asbestos: Trouble in the Air from Maryland Rock Quarry . . . . . . . . . . . . . . 237 Speaking Up for an Imperiled CEQ. ........................ 240read more
Citations
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Journal ArticleDOI
Fluidity Parameters of Lipid Regions Determined by Fluorescence Polarization
Journal ArticleDOI
Membrane lipid composition and cellular function.
Arthur A. Spector,Mark A. Yorek +1 more
TL;DR: Membrane fatty acid composition, phospholipid composition, and cholesterol content can be modified in many different kinds of intact mammalian cells, and many of the functional responses probably are caused directly by the membrane lipid structural changes, which affect either bulk lipid fluidity or specific lipid domains.
Journal ArticleDOI
Principles governing amino acid composition of integral membrane proteins: Application to topology prediction
Gábor E. Tusnády,István Simon +1 more
TL;DR: The method successfully predicted all the transmembrane segments in 143 proteins out of the 158, and for 135 of these proteins both the membrane spanning regions and the topologies were predicted correctly.
Journal ArticleDOI
Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function.
TL;DR: The tendency of certain lipids to self-associate, their asymmetric distribution in SUVs, their preferential association with cholesterol in non-cocrystallizing mixtures, their temperature-induced transitions to the hexagonal phase and their inhibitory effect on penetration of hydrophobic residues of proteins partway into the bilayer can all be explained by their participation in intermolecular hydrogen bonding interactions.
References
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Journal ArticleDOI
Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
Michael P. Sheetz,S. J. Singer +1 more
TL;DR: It is proposed that membranes whose proteins and polar lipids are distributed asymmetrically in the two halves of the membrane bilayer can act as bilayer couples, i.e., theTwo halves can respond differently to a perturbation.
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The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy
TL;DR: It is concluded that thisospholipid fraction (which contains the majority of the choline-containing phospholipids and some phosphatidylethanolamine) forms the outer monolayer of the membrane.
Journal ArticleDOI
Asymmetrical lipid bilayer structure for biological membranes.
TL;DR: It is shown that the structure of the matrix of cellular membranes is a bimolecular leaflet of phospholipid molecules in which the polar heads reside on the outer surfaces of the bilayer, in contact with the aqueous environment.
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Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayers
TL;DR: It is concluded that the lipid packing in the outer monolayer of the erythrocyte membrane is comparable with a lateral surface pressure between 31 and 34.8 dynes/cm.
Journal ArticleDOI
Localization of red cell membrane constituents.
TL;DR: A new concept for the haemolytic behaviour of mixtures ofospholipases is proposed, based upon a highly asymmetric distribution of the phospholipids in a bimolecular leaflet, and taking into account some aspects of the action of phospholIPases towards red cell ghosts.