Journal ArticleDOI
Toxicity of oxysterols to human monocyte-macrophages
Katharine Clare,Simon J. Hardwick,Keri L.H. Carpenter,Nishanthi Weeratunge,Malcolm J. Mitchinson +4 more
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TLDR
The cytotoxic potency of 26-hydroxycholesterol was the greatest and the 7-position derivatives also produced marked cell damage, though at higher concentrations than for 26-Hydroxych cholesterol, of the oxysterols assessed.About:
This article is published in Atherosclerosis.The article was published on 1995-11-01. It has received 138 citations till now. The article focuses on the topics: Oxysterol & Toxicity.read more
Citations
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Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
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Oxysterols and atherosclerosis
Andrew J. Brown,Wendy Jessup +1 more
TL;DR: There are a number of significant and quite widespread problems with current literature which preclude more than a tentative suggestion that oxysterol have a causal role in atherogenesis, and further studies are necessary to definitively determine the role of oxysterols in atherosclerosis.
Journal ArticleDOI
Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo
Andrew D. Watson,Norbert Leitinger,Mohamad Navab,Kym F. Faull,Sohvi Hörkkö,Joseph L. Witztum,Wulf Palinski,Dawn C. Schwenke,Robert G. Salomon,Wei Sha,Ganesamoorthy Subbanagounder,Alan M. Fogelman,Judith A. Berliner +12 more
TL;DR: Two of three molecules present in MM-LDL and Ox-PAPC that induce monocyte-endothelial interactions are determined and suggest that specific oxidized derivatives of arachidonic acid-containing phospholipids may be important initiators of atherogenesis.
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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
TL;DR: The biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases are reviewed and the potential therapeutic opportunities targeting ROS will be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.
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Oxysterols Friends, Foes, or Just Fellow Passengers?
Ingemar Björkhem,Ulf Diczfalusy +1 more
TL;DR: The present review is a critical evaluation of the literature on oxysterols, in particular, the in vivo evidence for a role of oxysterol as physiological regulators of cholesterol homeostasis and as atherogenic factors.
References
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity
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Binding Site on Macrophages that Mediates Uptake and Degradation of Acetylated Low Density Lipoprotein, Producing Massive Cholesterol Deposition
TL;DR: It is hypothesized that this macrophage uptake mechanism may mediate the degradation of denatured LDL in the body and thus serve as a "backup" mechanism for the previously described receptor-mediated degradation of native LDL that occurs in parenchymal cells.
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Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
TL;DR: The cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques and the Foam Cell in Familial Hypercholesterolemia are studied.
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Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Seppo Ylä-Herttuala,Wulf Palinski,Michael E. Rosenfeld,Sampath Parthasarathy,Thomas E. Carew,Susan Butler,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively modified in vitro.