Transforming Growth Factor-β Induces Collagenase-3 Expression by Human Gingival Fibroblasts via p38 Mitogen-activated Protein Kinase
Laura Ravanti,Lari Häkkinen,Hannu Larjava,Ulpu Saarialho-Kere,Marco Foschi,Jiahuai Han,Veli-Matti Kähäri +6 more
TLDR
The results show that TGF-β-elicited induction of MMP-13 expression by gingival fibroblasts is dependent on the activity of p38 MAPK and the presence of functional AP-1 dimers, and suggest a role for M MP-13 in rapid turnover of collagenous matrix during repair of gingivals wounds, which heal with minimal scarring.About:
This article is published in Journal of Biological Chemistry.The article was published on 1999-12-24 and is currently open access. It has received 219 citations till now. The article focuses on the topics: Transforming growth factor & Wound healing.read more
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Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration
TL;DR: Data suggest that PI3K-Akt signaling is required for TGFβ-induced transcriptional responses, EMT, and cell migration in 4T1 and EMT6 breast tumor cells.
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Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Nicholas J. Laping,Eugene T. Grygielko,A. Mathur,S. Butter,J. Bomberger,C. Tweed,W. Martin,James A. Fornwald,Ruth Lehr,John D. Harling,Laramie Mary Gaster,James F. Callahan,Barbara A. Olson +12 more
TL;DR: Data indicate that some matrix markers that are stimulated by TGF-beta1 are mediated via the p38 MAPK pathway, whereas others seem to be activated via ALK5 signaling independent of the p 38 MAPK pathways.
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Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.
Delphine Javelaud,Alain Mauviel +1 more
TL;DR: How MAPKs modulate the outcome of Smad activation by TGF-β, and how cross-signaling mechanisms between the Smad and MAPK pathways may take place and affect cell fate in the context of carcinogenesis are focused on.
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Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells.
TL;DR: Results indicate that ERK‐dependent R‐Smad linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells.
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Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer.
Erja Kerkelä,Ulpu Saarialho-Kere +1 more
TL;DR: The present role of MMPs in the development and progression of cancer, focusing on non‐melanoma skin cancers basal (BCC) and squamous (SCC) cell carcinoma, and the possible influence of M MPs in their differences is discussed.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
TL;DR: The results indicate that the activation of Raf is suppressed and that its inactivation is accelerated by a downstream component(s) of the MAP kinase pathway.
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Matrix Metalloproteinases: A Review
Henning Birkedal-Hansen,William G. I. Moore,M.K. Bodden,L.J. Windsor,B. Birkedal-Hansen,Arthur A. Decarlo,Jeffrey A. Engler +6 more
TL;DR: The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors.
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A synthetic inhibitor of the mitogen-activated protein kinase cascade.
TL;DR: Results indicate that the MAPK pathway is essential for growth and maintenance of the ras-transformed phenotype and PD 098059 is an invaluable tool that will help elucidate the role of theMAPK cascade in a variety of biological settings.
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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
Ana Cuenda,John Rouse,Yair N. Doza,Roger Meier,Philip Cohen,Timothy Francis Gallagher,Peter R. Young,John C. Lee +7 more
TL;DR: It is established that MAPKAP kinase‐2 is a physiological RK substrate, and that HSP27 is phosphorylated by MAPK AP kinase-2 in vivo.