Journal ArticleDOI
Trichomonas vaginalis: Pathogenesis, Symbiont Interactions, and Host Cell Immune Responses.
TLDR
Recent Tv research has uncovered new players that contribute to multifactorial mechanisms of host-parasite adherence and killing, and has examined the relationship between Tv and vaginal bacteria.About:
This article is published in Trends in Parasitology.The article was published on 2018-08-01. It has received 69 citations till now. The article focuses on the topics: Immune system & Trichomonas Infection.read more
Citations
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Journal ArticleDOI
Trichomonas vaginalis extracellular vesicles are internalized by host cells using proteoglycans and caveolin-dependent endocytosis.
TL;DR: Mechanisms used to drive host:pathogen interactions are revealed and the understanding of how EVs are internalized by target cells to allow cross-talk between different cell types is further understood.
Journal ArticleDOI
Biting Off What Can Be Chewed: Trogocytosis in Health, Infection, and Disease
TL;DR: A picture is emerging in which trogocytosis plays critical roles in normal physiology, infection, and disease, and an ever-evolving list of functions associated with this process.
Journal ArticleDOI
Trichomonas vaginalis and Mycoplasma hominis: new tales of two old friends.
Daniele Dessì,Valentina Margarita,Anna Rita Cocco,Alessandra Marongiu,Pier Luigi Fiori,Paola Rappelli +5 more
TL;DR: The identification of a novel species belonging to the class of Mollicutes exclusively associated to T. vaginalis opens new perspectives in the research of the complex series of events taking place in the multifaceted world of the vaginal microbiota, both under normal and pathological conditions.
Journal ArticleDOI
Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.
Angelica M. Riestra,J. Andrés Valderrama,Kathryn A. Patras,Sharon D Booth,Xing Yen Quek,Chih-Ming Tsai,Victor Nizet,Victor Nizet +7 more
TL;DR: These findings mechanistically dissect how T. vaginalis contributes to the production of the proinflammatory IL-1β cytokine and uncover pyroptosis as a mechanism by which the parasite can trigger host macrophage cell death.
Journal ArticleDOI
Chitosan-based systems aimed at local application for vaginal infections.
Victor Hugo Sousa Araujo,Maurício Palmeira Chaves de Souza,Gabriela Corrêa Carvalho,Jonatas Lobato Duarte,Marlus Chorilli +4 more
TL;DR: In this paper, a review aimed to analyze the studies that used chitosan to develop mucoadhesive drug delivery systems for the treatment of local vaginal infections, which demonstrated that chitosa is a promising device for treating vaginal infectious diseases, due to the intrinsic antimicrobial activity of this biopolymer.
References
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Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Vaginal microbiome of reproductive-age women
Jacques Ravel,Pawel Gajer,Zaid Abdo,G. Maria Schneider,Sara S. K. Koenig,Stacey L. McCulle,Shara Karlebach,Reshma Gorle,Jennifer Russell,Carol O. Tacket,Rebecca M. Brotman,Catherine C. Davis,Kevin A. Ault,Ligia Peralta,Larry J. Forney +14 more
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
Journal ArticleDOI
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
Jane M. Carlton,Robert P. Hirt,Joana C. Silva,Arthur L. Delcher,Michael C. Schatz,Qi Zhao,Jennifer R. Wortman,Shelby L. Bidwell,U. Cecilia M. Alsmark,Sébastien Besteiro,Thomas Sicheritz-Pontén,Christophe Noël,Joel B. Dacks,Peter G. Foster,Cedric Simillion,Yves Van de Peer,Diego Miranda-Saavedra,Geoffrey J. Barton,Gareth D. Westrop,Sylke Müller,Daniele Dessì,Pier Luigi Fiori,Qinghu Ren,Ian T. Paulsen,Hanbang Zhang,Felix D. Bastida-Corcuera,Augusto Simoes-Barbosa,Mark T. Brown,Richard D. Hayes,Mandira Mukherjee,Cheryl Y. M. Okumura,Rachel E. Schneider,Alias J. Smith,Stepanka Vanacova,Maria Villalvazo,Brian J. Haas,Mihaela Pertea,Tamara Feldblyum,T. Utterback,Chung-Li Shu,Kazutoyo Osoegawa,Pieter J. de Jong,Ivan Hrdy,Lenka Horváthová,Zuzana Zubáčová,Pavel Dolezal,Shehre-Banoo Malik,John M. Logsdon,Katrin Henze,Arti Gupta,Ching C. Wang,R. L. Dunne,Jacqueline A. Upcroft,Peter Upcroft,Owen White,Steven L. Salzberg,Petrus Tang,Cheng-Hsun Chiu,Ying-Shiung Lee,T. Martin Embley,Graham H. Coombs,Jeremy C. Mottram,Jan Tachezy,Claire M. Fraser-Liggett,Patricia J. Johnson +64 more
TL;DR: The genome sequence of the protist Trichomonas vaginalis predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Journal ArticleDOI
The Prevalence of Trichomonas vaginalis Infection among Reproductive-Age Women in the United States, 2001–2004
Madeline Y. Sutton,Maya R. Sternberg,Emilia H. Koumans,Geraldine M. McQuillan,Stuart M. Berman,Lauri E. Markowitz +5 more
TL;DR: A significant racial disparity exists; the prevalence among non-Hispanic black women was 10.3 times higher than that amongnon-Hispanic white and Mexican American women, and Optimal prevention and control strategies for T. vaginalis infection should be explored as a means of closing the racial disparity gaps and decreasing adverse health outcomes.
Book ChapterDOI
Galectins as pattern recognition receptors: structure, function, and evolution.
TL;DR: An additional level of functional complexity has emerged with the most recent findings that some parasites "subvert" the recognition roles of the vector/host galectins for successful attachment or invasion.