Journal ArticleDOI
Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway.
TLDR
Results indicated that TP induced oxidative damage in NRK-52E cells by facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway.About:
This article is published in Toxicology in Vitro.The article was published on 2019-08-01. It has received 19 citations till now. The article focuses on the topics: FYN & Cell damage.read more
Citations
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Journal ArticleDOI
Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism
Di Yu,Di Yu,Yang Liu,Yiqiang Zhou,Victor Ruiz-Rodado,Mioara Larion,Guowang Xu,Chunzhang Yang +7 more
TL;DR: It is demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de novo synthesis, and triptolide served as a potent NRF2 inhibitor, which exhibited selective cytotoxicity to patient-derived IDH 1-mutation glioma cells in vitro and in vivo.
Iconographies supplémentaires de l'article : Toxicity of triptolide and the molecular mechanisms involved
TL;DR: Tripterygium wilfordii Hook f. (TWHF) is a major active and toxic ingredient isolated from the traditional Chinese herb Tripterygiam wilfordius (TP), and its toxicity has been extensively studied.
Journal ArticleDOI
Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway.
Wei Yu Fang,Yu-Ting Tseng,Yu-Ting Tseng,Tzu-Ying Lee,Yin-Chih Fu,Wan-Hsuan Chang,Wan-Wen Lo,Chih Lung Lin,Yi-Ching Lo +8 more
TL;DR: In this paper, the effects of triptolide on skeletal muscle atrophy were investigated in LPS-treated C2C12 myotubes and C57BL/6 mice.
Book ChapterDOI
Perspectives on the Clinical Development of NRF2-Targeting Drugs.
TL;DR: This review describes the electrophilic and non-electrophilic NRF2 activators with clinical projection in various chronic diseases and analyzes the status ofNRF2 inhibitors, which are for the moment in a proof-of-concept stage.
Journal ArticleDOI
Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer’s Disease-Related Epileptic Seizures
TL;DR: Understanding the role of GSK-3 in AD-associated seizures and epilepsy may help researchers develop new therapeutic approach that can manage seizure and epilepsy in AD patients as well as decelerate the progression of AD.
References
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Journal ArticleDOI
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
TL;DR: This work phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/β-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner, and proposes a “dual degradation” model to describe the regulation of NRF2 under different pathophysiological conditions.
Journal ArticleDOI
GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2
Abhinav K. Jain,Anil K. Jaiswal +1 more
TL;DR: It is demonstrated that GSK-3β acts upstream of Fyn kinase in control of nuclear export of Nrf2, and hydrogen peroxide phosphorylates tyrosine 216 of GSK -3β leads to activation of G SK-3 β, which activates Fyn and leads to nuclear export, ubiquitination, and degradation of NRF2.
Journal ArticleDOI
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
TL;DR: The structural parameters of the interaction of Nrf2 with the GSK-3/β-TrCP axis is established and its functional relevance in the regulation of NRF2 by the signaling pathways that impinge on G SKS-3 is established.
Journal ArticleDOI
The Roles of NRF2 in Modulating Cellular Iron Homeostasis.
Michael J. Kerins,Aikseng Ooi +1 more
TL;DR: This work has identified that several genes involved in heme synthesis, hemoglobin catabolism, iron storage, and iron export are under the control of NRF2, a nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor which regulates several genesinvolved in iron metabolism.
Journal ArticleDOI
The complexity of the Nrf2 pathway: Beyond the antioxidant response
TL;DR: The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an efficient and pivotal line of defensive to counteract environmental insults and endogenous stressors as mentioned in this paper.