TSH stimulates leptin secretion by a direct effect on adipocytes.
C Menendez,Roberto Baldelli,Jesus P. Camiña,B Escudero,R. Peino,Carlos Dieguez,Felipe F. Casanueva +6 more
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TLDR
The results suggest that leptin and the thyroid axis maintain a complex and dual relationship and open the possibility that plasmatic changes in TSH may contribute to the regulation of leptin pulses.Abstract:
Leptin is a circulating hormone secreted by adipose tissue which acts as a signal to the central nervous system where it regulates energy homeostasis and neuroendocrine processes. Although leptin modulates the secretion of several pituitary hormones, no information is available regarding a direct action of pituitary products on leptin release. However, it has been pointed out that leptin and TSH have a coordinated pulsatility in plasma. In order to test a direct action of TSH on in vitro leptin secretion, a systematic study of organ cultures of human omental adipose tissue was performed in samples obtained at surgery from 34 patients of both sexes during elective abdominal surgery. TSH powerfully stimulated leptin secretion by human adipose tissue in vitro. In contrast, prolactin, ACTH, FSH and LH were devoid of action. These results suggest that leptin and the thyroid axis maintain a complex and dual relationship and open the possibility that plasmatic changes in TSH may contribute to the regulation of leptin pulses.read more
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Obesity and thyroid function.
TL;DR: A moderate elevation of thyroid hormone concentrations increase the resting energy expenditure (REE) in obese individuals as discussed by the authors, which is associated with increased TSH and T3 values in or slightly above the upper normal range.
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Gianluca Iacobellis,Maria Cristina Ribaudo,Alessandra Zappaterreno,Concetta Valeria Iannucci,Frida Leonetti +4 more
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Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.
TL;DR: Recommendations are offered for the diagnosis, management, and screening of thyroid disorders in patients with diabetes mellitus, including the treatment of diabetic patients planning a pregnancy and an algorithm for a correct approach of these disorders when linked.
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Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area
TL;DR: The data provide the first evidence that IR is an independent risk factor for nodule formation in an iodine-deficient environment and patients with MetS have significantly increased thyroid volume and nodule prevalence.
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Role of leptin in hypothalamic–pituitary function
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