Journal ArticleDOI
Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis.
Natalia S. Novikova,Anastasia S. Diatlova,Kristina Z. Derevtsova,Elena A. Korneva,Tamara V. Viktorovna,Yuri Ostrinki,Lital Abraham,Shir Quinn,Yahel Segal,Leonid P. Churilov,Miri Blank,Yehuda Shoenfeld,Rina Aharoni,Howard Amital +13 more
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TLDR
It is suggested that tuftsin-phosphorylcholine (TPC) may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.About:
This article is published in Journal of Neuroimmunology.The article was published on 2019-12-15. It has received 9 citations till now. The article focuses on the topics: Experimental autoimmune encephalomyelitis & Autoimmune disease.read more
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Allen Reference Atlas: A Digital Color Brain Atlas of the C57BL/6J Male Mouse.ByHong Wei Dong. Hoboken (New Jersey): John Wiley & Sons. $195.00 (spiral). ix + 366 p.; ill.; no index. 978‐0‐470‐05408‐6. [CD‐ROM included.] 2008.
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Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis?
Juliana Helena dos Santos de Toledo,Thais Fernanda de Campos Fraga-Silva,Patrícia Aparecida Borim,Larissa Ragozo Cardoso de Oliveira,Evelyn da Silva Oliveira,Larissa Lucena Périco,Clélia Akiko Hiruma-Lima,Adriana Aparecida Lopes de Souza,Carlos Alberto Ferreira de Oliveira,Pedro de Magalhães Padilha,Marcos Felipe Pinatto-Botelho,Alcindo A. Dos Santos,Alexandrina Sartori,Sofia Fernanda Gonçalves Zorzella-Pezavento +13 more
TL;DR: It is indicated that LAD-βSe, and possibly other derivatives containing Se, are able to reach the CNS and have the potential to be used as preventive and therapeutic measures in distinct clinical forms of MS.
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9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation
Jie Lv,Wei Zhuang,Wei Zhuang,Yan Zhang,Ling Xie,Zhenglong Xiang,Qingjie Zhao,Xiangrui Jiang,Jingshan Shen,Changsheng Du,Changsheng Du +10 more
TL;DR: Wang et al. as discussed by the authors investigated whether 9,10-Anhydrodehydroartemisin (ADART), a compound derived from artemisinin, could decrease demyelination in EAE and the underlying mechanisms.
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Immunomodulation of Murine Chronic DSS-Induced Colitis by Tuftsin-Phosphorylcholine.
Dana Ben-Ami Shor,Dana Ben-Ami Shor,Jordan Lachnish,Tomer Bashi,Shani Dahan,Asaf Shemer,Yahel Segal,Ora Shovman,Gilad Halpert,Alexander Volkov,Iris Barshack,Howard Amital,Miri Blank,Yehuda Shoenfeld +13 more
TL;DR: The potential immunomodulatory effects of oral administration of TPC in a chronic colitis murine model was demonstrated and it was demonstrated that TPC reduced inflammatory process ex vivo in peripheral blood lymphocytes (PBLs) and in biopsies from giant-cell arteritis.
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Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review.
Amirhossein Azari Jafari,Mojtaba Keikha,Seyyedmohammadsadeq Mirmoeeni,Mohammad Taghi Rahimi,Reza Jafari +4 more
TL;DR: A systematic review of the use of live parasites or parasitic products in the treatment of mouse models of systemic lupus erythematosus (SLE) was conducted in this article.
References
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Multiple Sclerosis: Mechanisms and Immunotherapy
TL;DR: Major challenges for MS research involve understanding the mechanisms of disease progression, developing treatment for progressive MS, and determining the degree to which progressive disease can be prevented by early treatment.
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Association Between Parasite Infection and Immune Responses in Multiple Sclerosis
Jorge Correale,Mauricio F. Farez +1 more
TL;DR: To assess whether parasite infection is correlated with a reduced number of exacerbations and altered immune reactivity in multiple sclerosis (MS), a large number of patients with confirmed or suspected cases of multiple sclerosis are treated with a parasite infection.
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‘Tuftsin’: a Natural Phagocytosis Stimulating Peptide
Victor A. Najjar,Kenji Nishioka +1 more
TL;DR: The whole stimulatory effect of leucokinin can be ascribed to a single peptide fragment liberated by a specific enzyme in the outer membrane of the neutrophile, referred to as ‘tuftsin’ (after Tufts University) and to the enzyme as leukokininase.
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Astrocytes in multiple sclerosis : A product of their environment
TL;DR: Recent data supporting the idea that astrocytes play a complex role in the regulation of CNS autoimmunity are summarized.
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The hygiene hypothesis in autoimmunity: the role of pathogens and commensals
TL;DR: The importance of innate immune receptors, in particular Toll-like receptor, in mediating the protective effect of pathogens and commensals on autoimmunity is discussed.