Tuned thalamic excitation is amplified by visual cortical circuits
Anthony D Lien,Massimo Scanziani +1 more
TLDR
The results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selectiveThalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamus and cortex excitation.Abstract:
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.read more
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References
More filters
Journal ArticleDOI
Looking back: corticothalamic feedback and early visual processing.
Javier Cudeiro,Adam M. Sillito +1 more
TL;DR: The essential point is that the perspective of higher-level sensory mechanisms shifts and modulates the thalamic circuitry in ways that optimize abstraction of a meaningful representation of the external world.
Journal ArticleDOI
Intervening inhibition underlies simple-cell receptive field structure in visual cortex
TL;DR: Neurons with either segregated or overlapped On/Off spike subfields had substantial overlaps between all the four synaptic subfields, suggesting that the dichotomy of receptive-field structures may arise from a fine-tuning of the spatial arrangement of synaptic inputs.
Journal ArticleDOI
Prediction of orientation selectivity from receptive field architecture in simple cells of cat visual cortex.
TL;DR: The results show that the spatial organization of the receptive field can account for a large fraction of the orientation selectivity of simple cells.
Journal ArticleDOI
In vivo Labeling of Constellations of Functionally Identified Neurons for Targeted in vitro Recordings.
Anthony D Lien,Massimo Scanziani +1 more
TL;DR: The ability to perform in vitro recordings from neurons with known functional properties opens up exciting new possibilities for dissecting the cellular, synaptic, and circuit mechanisms that underlie neuronal function in vivo.
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