Tuned thalamic excitation is amplified by visual cortical circuits
Anthony D Lien,Massimo Scanziani +1 more
TLDR
The results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selectiveThalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamus and cortex excitation.Abstract:
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.read more
Citations
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Visual Evidence Accumulation Guides Decision-Making in Unrestrained Mice.
TL;DR: By leveraging a large dataset to quantitatively characterize decision-making behavior, mice are established as suitable for neural circuit manipulation studies and it is demonstrated that mice accumulate visual evidence, demonstrating that this strategy for reducing uncertainty in decision- making is used by animals with diverse visual systems.
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Visual physiology of the layer 4 cortical circuit in silico.
Anton Arkhipov,Nathan W. Gouwens,Yazan N. Billeh,Sergey L. Gratiy,Ramakrishnan Iyer,Ziqiang Wei,Zihao Xu,Reza Abbasi-Asl,Jim Berg,Michael A. Buice,Nicholas Cain,Nuno Maçarico da Costa,Saskia E. J. de Vries,Daniel J. Denman,Séverine Durand,David Feng,Tim Jarsky,Jérôme Lecoq,Brian Lee,Lu Li,Stefan Mihalas,Gabriel Koch Ocker,Shawn R. Olsen,R. Clay Reid,Gilberto J. Soler-Llavina,Staci A. Sorensen,Quanxin Wang,Jack Waters,Massimo Scanziani,Christof Koch +29 more
TL;DR: A biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo-cortical visual inputs is released, demonstrating the importance of functional rules of cortical wiring and enabling a next generation of data-driven models of in vivo neural activity and computations.
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Cell types, circuits, and receptive fields in the mouse visual cortex.
TL;DR: The advances in the understanding of the mouse visual cortex are described, including neural coding, the role of different cell types, and links between vision and behavior, and discusses how recent findings and new approaches can guide future studies.
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Retinal origin of direction selectivity in the superior colliculus
Xuefeng Shi,Jad Barchini,Hector Acaron Ledesma,David Koren,Yanjiao Jin,Yanjiao Jin,Xiaorong Liu,Wei Wei,Jianhua Cang +8 more
TL;DR: This work optogenetically isolates the retinal inputs that individual direction-selective SC neurons receive and finds that they are already selective as a result of precisely converging inputs from similarly tuned retinal ganglion cells.
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Development, form, and function of the mouse visual thalamus.
TL;DR: The mouse as a model organism has moved to the forefront as a tractable experimental platform to examine cell type-specific relations and current knowledge about the development, structure, and function of the mouse dLGN is highlighted.
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