Tuned thalamic excitation is amplified by visual cortical circuits
Anthony D Lien,Massimo Scanziani +1 more
TLDR
The results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selectiveThalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamus and cortex excitation.Abstract:
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.read more
Citations
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Feedforward Inhibition Allows Input Summation to Vary in Recurrent Cortical Networks.
TL;DR: To understand input-output transformations in cortical networks, spiking responses from visual cortex of awake mice of either sex are recorded while pairing sensory stimuli with optogenetic perturbation of excitatory and parvalbumin-positive inhibitory neurons.
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Efficient sensory cortical coding optimizes pursuit eye movements.
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Linear transformation of the encoding mechanism for light intensity underlies the paradoxical enhancement of cortical visual responses by sevoflurane
Alessandro Arena,Jacopo Lamanna,Marco Gemma,Maddalena Ripamonti,Giuliano Ravasio,Vincenzo Zimarino,Assunta De Vitis,Luigi Beretta,Antonio Malgaroli +8 more
TL;DR: It is shown that the anaesthetic sevoflurane strongly silences the brain but potentiates in a dose‐ and frequency‐dependent manner the cortical visual response, arising from a linear scaling by sev ofluranes of the power‐law relation between light intensity and the cortical response.
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Visual physiology of the Layer 4 cortical circuit in silico
Anton Arkhipov,Nathan W. Gouwens,Yazan N. Billeh,Sergey L. Gratiy,Ramakrishnan Iyer,Ziqiang Wei,Zihao Xu,Jim Berg,Michael A. Buice,Nicholas Cain,Nuno Maçarico da Costa,Saskia E. J. de Vries,Daniel J. Denman,Séverine Durand,David Feng,Tim Jarsky,Jérôme Lecoq,Brian Lee,Lu Li,Stefan Mihalas,Gabriel Koch Ocker,Shawn R. Olsen,R. Clay Reid,Gilberto J. Soler-Llavina,Staci A. Sorensen,Quanxin Wang,Jack Waters,Massimo Scanziani,Christof Koch +28 more
TL;DR: A biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo-cortical visual inputs is reported, highlighting the importance of functional rules of cortical wiring and enabling a next generation of data-driven models of in vivo neural activity and computations.
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Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex
TL;DR: This work addresses the impact of two populations of cortico-fugal neurons in mouse VC in the learning and performance of a visual detection task and shows that the ablation of striatal projecting neurons reduces learning speed, whereas theAblation of superior colliculus projecting neurons does not impact learning but reduces detection sensitivity.
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