Tuned thalamic excitation is amplified by visual cortical circuits
Anthony D Lien,Massimo Scanziani +1 more
TLDR
The results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selectiveThalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamus and cortex excitation.Abstract:
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.read more
Citations
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TL;DR: A novel statistical model is developed that decomposes the population response into modes and predicts the distribution of spiking activity in the ganglion cell population with high accuracy; it is found that the modes represent localized features of the visual stimulus that are distinct from the features represented by single neurons.
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Functional implications of orientation maps in primary visual cortex
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Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus
Wei Shi,Wei Shi,Anjin Xianyu,Anjin Xianyu,Zhi Han,Zhi Han,Xing Tang,Zhizhong Li,Haining Zhong,Tianyi Mao,Kun Huang,Song-Hai Shi,Song-Hai Shi +12 more
TL;DR: This study reveals lineage relationship to be a critical regulator of nonlaminated thalamus development and organization and reports an intricate ontogenetic logic of mouse thalamic structures.
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Multiscale and multimodal reconstruction of cortical structure and function
Nicholas L. Turner,Thomas Macrina,J. Alexander Bae,Runzhe Yang,Alyssa Wilson,Casey M Schneider-Mizell,Kisuk Lee,Kisuk Lee,Ran Lu,Jingpeng Wu,Agnes L. Bodor,Adam Bleckert,Derrick Brittain,Emmanouil Froudarakis,Sven Dorkenwald,Forrest Collman,Nico Kemnitz,Dodam Ih,William Silversmith,Jonathan Zung,Aleksandar Zlateski,Ignacio Tartavull,Szi-chieh Yu,Sergiy Popovych,Shang Mu,William Wong,Chris S. Jordan,Manuel Castro,JoAnn Buchanan,Daniel J. Bumbarger,Marc Takeno,Russel Torres,Gayathri Mahalingam,Leila Elabbady,Yang Li,Erick Cobos,Pengcheng Zhou,Shelby Suckow,Lynne Becker,Liam Paninski,Franck Polleux,Jacob Reimer,Andreas S. Tolias,Andreas S. Tolias,R. Clay Reid,Nuno Maçarico da Costa,H. Sebastian Seung +46 more
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Adaptive Processes in Thalamus and Cortex Revealed by Silencing of Primary Visual Cortex during Contrast Adaptation.
TL;DR: The majority of adaptation seen in V1 neurons arises through local activity-dependent processes, with smaller contributions from dLGN inheritance and synaptic depression at the thalamo-cortical synapse.
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