Tuned thalamic excitation is amplified by visual cortical circuits
Anthony D Lien,Massimo Scanziani +1 more
TLDR
The results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selectiveThalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamus and cortex excitation.Abstract:
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.read more
Citations
More filters
Posted ContentDOI
Primate neocortex performs balanced sensory amplification
TL;DR: Sensory cortex uses balanced excitatory and inhibitory circuitry to boost weak signals while maintaining fast sensory dynamics in a changing environment.
Journal ArticleDOI
Gamma frequency feedback inhibition accounts for key aspects of orientation selectivity in V1
TL;DR: Simple rules underlie the selection of which cells fire in cortical networks are suggested, including the E%max model, which performs a type of winner-take-all computation that obeys simple rules.
Posted ContentDOI
Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation
TL;DR: In this paper, principal cells (PCs) and parvalbumin positive (PV) responses were examined in mouse anterior lateral motor cortex (ALM) and barrel cortex (S1) upon PV photostimulation.
Posted ContentDOI
Interneuron subtypes enable independent modulation of excitatory and inhibitory firing rates after sensory deprivation
TL;DR: In this paper, the role of interneuron subtypes in regulating cortical dynamics during deprivation-induced plasticity was investigated in a micro-circuit network model of the visual cortex.
Posted ContentDOI
Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics.
Renata Batista-Brito,Renata Batista-Brito,Antara Majumdar,Antara Majumdar,Alejandro Nuno,Martin Vinck,Martin Vinck,Jessica A. Cardin +7 more
TL;DR: Data support a key role for early developmental Nrg1/ErbB4 signaling in PV interneurons as powerful mechanism underlying the maturation of both the inhibitory and excitatory components of cortical circuits.
References
More filters
Journal ArticleDOI
The Psychophysics Toolbox.
TL;DR: The Psychophysics Toolbox is a software package that supports visual psychophysics and its routines provide an interface between a high-level interpreted language and the video display hardware.
Journal ArticleDOI
Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: This method is used to examine receptive fields of a more complex type and to make additional observations on binocular interaction and this approach is necessary in order to understand the behaviour of individual cells, but it fails to deal with the problem of the relationship of one cell to its neighbours.
Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Georg Nagel,Tanjef Szellas,Wolfram Huhn,Suneel Kateriya,Nona Adeishvili,Peter Berthold,Doris Ollig,Peter Hegemann,Ernst Bamberg +8 more
TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
Journal ArticleDOI
Modulation of Visual Responses by Behavioral State in Mouse Visual Cortex
TL;DR: The response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed demonstrated powerful cell-type-specific modulation of visual processing by behavioral state in awake mice.
Related Papers (5)
Highly Selective Receptive Fields in Mouse Visual Cortex
Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more