Journal ArticleDOI
Two new quassinoids and other constituents from Picrasma javanica wood, and their biological activities
Prema,Prema,Chin Piow Wong,Alfarius Eko Nugroho,Maurice D. Awouafack,Maurice D. Awouafack,Yi Yi Win,Nwet Nwet Win,Hla Ngwe,Hiroshi Morita,Hiroyuki Morita +10 more
TLDR
Two new quassinoids, (16R)-methoxyjavanicin B (1) and (16S)- methoxy javanic in B (2), along with seven known compounds, were isolated during the phytochemical investigation of the CHCl3 soluble portion of the MeOH extract of P. javanica wood.Abstract:
Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from Myanmar medicinal plants, two new quassinoids, (16R)-methoxyjavanicin B (1) and (16S)-methoxyjavanicin B (2), along with seven known compounds (3–9), were isolated during the phytochemical investigation of the CHCl3 soluble portion of the MeOH extract of P. javanica wood. The structures of the new compounds were elucidated by analyses of their spectroscopic data (1D- and 2D-NMR, HRESIMS, and CD). A cytotoxicity assay revealed that compound 8 showed moderate activities against all tested cancer cell lines, the human lung (A549), breast (MCF7), and cervical (HeLa), and the normal fibroblast cell line, with IC50 values ranging from 48.6 to 65.9 μM. Furthermore, the antibacterial assay demonstrated that 1 and 2 had the highest activities (MIC value of 1.6 μM each), followed by 5 and 3 (MIC values of 3.1 and 6.3 μM, respectively) against the Gram-positive bacterium B. subtilis.read more
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Recent progress of antibacterial natural products: Future antibiotics candidates.
Jiangkun Dai,Jiangkun Dai,Jiangkun Dai,Rui Han,Yujie Xu,Na Li,Junru Wang,Wenjia Dan,Wenjia Dan +8 more
TL;DR: 256 natural products from 11 structural classes in the period of 2016-01/2020 selected by SciFinder with new compounds or new structures and MICs lower than 10 μg/mL or 10 μM as criterions will provide some effective antibacterial lead compounds for medicinal chemists.
Journal ArticleDOI
Computationally-assisted discovery and structure elucidation of natural products
TL;DR: In this review, several examples of recent studies that used computer technology to facilitate the discovery and structure determination of various natural products are provided.
Journal ArticleDOI
New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata.
Yusuke Hirasawa,Xin Dai,Jun Deguchi,Shota Hatano,Tadahiro Sasaki,Ruri Ohtsuka,Alfarius Eko Nugroho,Toshio Kaneda,Hiroshi Morita +8 more
TL;DR: Taberniacins A and B, new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata and showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Journal ArticleDOI
Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities.
Prema,Prema,Chin Piow Wong,Takeshi Kodama,Alfarius Eko Nugroho,Ahmad H El-Desoky,Maurice D. Awouafack,Yi Yi Win,Hla Ngwe,Ikuro Abe,Hiroshi Morita,Hiroyuki Morita +11 more
TL;DR: The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM, and revealed the potentAnti-VPR activities of (16R)-methoxyjavanicin B (7) and (16S)- methoxyJavanic in B (8), which were previously isolated from the Picrasma javanica wood.
Journal ArticleDOI
New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella
Dae-Won Ki,Ahmed H El-Desoky,Chin Piow Wong,Mohamed Abdel-Ghani,Ahmed A. El-Beih,Mineyuki Mizuguchi,Hiroyuki Morita +6 more
TL;DR: Three new polyacetylenic alcohols, siphonellanols A–C (1–3) were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt.
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