Ubiquitin and transcription: The SCF/Met4 pathway, a (protein-) complex issue.
Ikram Ouni,Karin Flick,Peter K. Kaiser +2 more
- Vol. 2, Iss: 3, pp 135-139
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TLDR
A recent study that describes the yeast transcriptional activator Met4 as a functional component of the very same Ubiquitin ligase that regulates its own activity highlights the close relation between transcription and the ubiquitin proteasome system.Abstract:
Ubiquitylation has emerged as an omnipresent factor at all levels of transcriptional regulation. A recent study that describes the yeast transcriptional activator Met4 as a functional component of the very same ubiquitin ligase that regulates its own activity highlights the close relation between transcription and the ubiquitin proteasome system.read more
Citations
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Journal ArticleDOI
The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
TL;DR: The diverse effects of ubiquitylation reflect the assembly of structurally distinct ubiquitin chains on target proteins.
Journal ArticleDOI
Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency
Matthew L. Bettini,Fan Pan,Maria Bettini,David Finkelstein,Jerold E. Rehg,Stefan Floess,Bryan D. Bell,Steven F. Ziegler,Jochen Huehn,Drew M. Pardoll,Dario A. A. Vignali +10 more
TL;DR: It is shown that a well-characterized Foxp3(gfp) reporter mouse, which expresses an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accelerated autoimmune diabetes on a NOD background.
Journal ArticleDOI
Protein degradation and the stress response
Karin Flick,Peter K. Kaiser +1 more
TL;DR: Contributions of the UPS to stress sensing, signaling, and response pathways are outlined to illustrate concepts and mechanisms by which protein modification with ubiquitin and proteasomal degradation of key regulators ensures cellular integrity during stress situations.
Journal ArticleDOI
Ubiquitin Signals Proteolysis-Independent Stripping of Transcription Factors
TL;DR: It is suggested that deubiquitination of the activator is critical for transcription activation, and a role for Ub and Cdc48 in transcriptional regulation and gene expression that is independent of proteolysis is illustrated.
Journal ArticleDOI
Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase
TL;DR: Targeted mutagenesis found that mutant Kelch deficient in its ability to interact with Cul3 failed to rescue the kelch cytoskeletal defects, suggesting that ubiquitin ligase activity is the principal activity required in vivo.
References
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Journal ArticleDOI
The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
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The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
Journal ArticleDOI
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
TL;DR: The ubiquitin-proteasome pathway has been shown to play an essential role in two proteolytic processes required for activation of the transcription factor NF-κB as discussed by the authors.
Journal ArticleDOI
Role of histone H2A ubiquitination in Polycomb silencing
Hengbin Wang,Liangjun Wang,Hediye Erdjument-Bromage,Miguel Vidal,Paul Tempst,Richard S. Jones,Yi Zhang +6 more
TL;DR: The purification and functional characterization of an E3 ubiquitin ligase complex that is specific for histone H2A is reported, and it is linked to Polycomb silencing, which is important in regulating chromatin dynamics and transcription.
Journal ArticleDOI
Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins
TL;DR: The primary aim of this review is to summarize the latest developments in the understanding of the different Ubl-protein modification systems, including the shared and unique features of these related pathways.