Journal ArticleDOI
Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi.
Daniela de Oliveira Toyama,Eduardo Britto dos Santos Diz Filho,Eduardo Britto dos Santos Diz Filho,Benildo Sousa Cavada,Bruno A.M. Rocha,Simone Cristina Buzzo de Oliveira,Simone Cristina Buzzo de Oliveira,Camila Aparecida Cotrim,Camila Aparecida Cotrim,Veronica C. G. Soares,Veronica C. G. Soares,Plínio Delatorre,Sergio Marangoni,Marcos H. Toyama +13 more
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TLDR
It is demonstrated that umbelliferone induces changes in structure and pharmacological activities of Bn IV, a lysine 49 secretory phospholipase A(2) (sPLA2) from Bothrops neuwiedi, and the pharmacological activity of this sPLA2 is driven by synergism of the C-terminal region with the α-helix motifs.About:
This article is published in Toxicon.The article was published on 2011-05-01. It has received 24 citations till now. The article focuses on the topics: Umbelliferone.read more
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Journal ArticleDOI
Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis
Renata Santos Rodrigues,Johara Boldrini-França,Fernando P.P. Fonseca,Pilar de la Torre,Flávio Henrique-Silva,Libia Sanz,Juan J. Calvete,Juan J. Calvete,Veridiana M. Rodrigues +8 more
TL;DR: Data support the view that venom composition is influenced by transcriptional and translational mechanisms and emphasize the value of combining proteomic and transcriptomic approaches to acquire a more complete understanding of the toxinological profile and natural history of the snake venom.
Journal ArticleDOI
Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: overview of the last decade.
Carla Cristine Neves Mamede,Bruna Barbosa de Sousa Simamoto,Déborah Fernanda da Cunha Pereira,Júnia de Oliveira Costa,Mariana Santos Matias Ribeiro,Fábio Luiz de Oliveira +5 more
TL;DR: The edematogenic, hyperalgesic and myotoxic effects caused by Brazilian bothropic venoms are analyzed in order to contribute to the study and elucidation of the mechanisms of action of its components and enable discoveries of more effective combined therapies in the treatment of local damages resulting from envenoming.
Journal ArticleDOI
Protective Effects of 7‐Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol‐Induced Myocardial Infarction in Rats
TL;DR: 7‐HC protects ISO‐induced MI in rats by its free radical scavenging and antihyperlipidaemic and antihypertrophic properties.
Journal ArticleDOI
Effect of chlorogenic acid (5-Caffeoylquinic Acid) isolated from Baccharis oxyodonta on the structure and pharmacological activities of secretory phospholipase A2 from Crotalus durissus terrificus.
Daniela de Oliveira Toyama,Marcelo J. P. Ferreira,Paulete Romoff,Oriana A. Fávero,Henrique Hessel Gaeta,Marcos H. Toyama +5 more
TL;DR: The results showed the potential application of 5CQA in the snake poisoning treatment and modulation of the pathological effect of inflammation induced by secretory PLA2, which induced massive bacterial cell destruction.
Journal ArticleDOI
Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2(I)→1(II))-α-D-glucopyranoside on adjuvant-induced arthritic rats.
TL;DR: It is suggested that the UFD has prominent antiarthritic impact which can be endorsed to itsAntiarthritic and antioxidant effects.
References
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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.
H. Schägger,G. von Jagow +1 more
TL;DR: A discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) system for the separation of proteins in the range from 1 to 100 kDa is described, and the omission of glycine and urea prevents disturbances which might occur in the course of subsequent amino acid sequencing.
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Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate.
TL;DR: All amino acids, including proline, are converted quantitatively to phenylthiocarbamyl compounds and these are stable enough to eliminate any need for in-line derivatization, providing results comparable in sensitivity and precision to those obtained by state-of-the-art ion-exchange analyzers.
Journal ArticleDOI
Flavonoids : old and new aspects of a class of natural therapeutic drugs
TL;DR: This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities.
Journal ArticleDOI
p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets: EVIDENCE THAT PROLINE-DIRECTED PHOSPHORYLATION IS NOT REQUIRED FOR MOBILIZATION OF ARACHIDONIC ACID BY cPLA2*
Ruth M. Kramer,Edda F. Roberts,Suzane L. Um,Angelika G. Börsch-Haubold,Steve P. Watson,Matthew J. Fisher,Joseph A. Jakubowski +6 more
TL;DR: It is found that prevention of proline-directed phosphorylation of cPLA2 in stimulated platelets did not attenuate its ability to release arachidonic acid from platelet phospholipids and the role of p38 kinase is concluded.
Journal ArticleDOI
Biochemical mechanisms of platelet activation
TL;DR: This review summarizes the current understanding of the biochemical pathways of platelet activation and inhibition, with specific emphasis on recent advances and unresolved issues.