Unrelated Donor Bone Marrow Transplantation for Myelodysplastic Syndrome in Children
Paul Woodard,Paul A. Carpenter,Stella M. Davies,Thomas G. Gross,Wensheng He,Mei-Jie Zhang,Biljana Horn,David A. Margolis,John P. Perentesis,Jean E. Sanders,Kirk R. Schultz,Adriana Seber,William G. Woods,Mary Eapen +13 more
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TLDR
Long-term disease-free survival after unrelated donor bone marrow transplantation for myelodysplastic syndrome in 118 patients aged ≤18 years is described and a matched adult unrelated donor is available, BMT should be offered as first-line therapy.Citations
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Umbilical cord blood banking: from personal donation to international public registries to global bioeconomy.
TL;DR: The different types of UCBBiobank, the organization of international registries of public UCB biobanks, the optimal size of national inventories, and the possibility of obtaining commercial products from donated units are examined, with a particular emphasis on the globalized bioeconomy ofUCB and its commerciality or lack thereof.
Journal ArticleDOI
Early hematopoietic stem cell transplant is associated with favorable outcomes in children with MDS
Angela R. Smith,Ellen C. Christiansen,John E. Wagner,Qing Cao,Margaret L. MacMillan,Heather E. Stefanski,Barbara A. Trotz,Michael J. Burke,Michael R. Verneris +8 more
TL;DR: Although hematopoietic stem cell transplantation is the treatment of choice for childhood myelodysplastic syndrome, there is no consensus regarding patient or disease characteristics that predict outcomes.
Journal ArticleDOI
Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome: A Review
TL;DR: Current recommendations and controversies surrounding HSCT for MDS are summarized, as well as the use of novel therapeutics in the peri-transplant period.
Journal ArticleDOI
Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation
Nicolas Waespe,Machiel van den Akker,Robert J. Klaassen,Lani Lieberman,Meredith S. Irwin,Salah Ali,Mohamed Abdelhaleem,Bozana Zlateska,Mira Liebman,Michaela Cada,Tal Schechter,Yigal Dror +11 more
TL;DR: Azacitidine treatment prior to hematopoietic stem cell transplantation was well tolerated in pediatric patients with advanced myelodysplastic syndrome, led to partial or complete bone marrow response in seven of eight patients (87.5%), and correlated with superior event-free survival in this cohort.
Journal ArticleDOI
Hematopoietic stem cell transplantation in children with refractory cytopenia of childhood: single-center experience using high-dose cytarabine containing myeloablative and aplastic anemia oriented reduced-intensity conditioning regimens.
TL;DR: Further study is needed to evaluate the efficacy of RIC for children with RCC with an expectation for reduction of late effects such as growth retardation and infertility.
References
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Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
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Survival Analysis: Techniques for Censored and Truncated Data
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TL;DR: Survival analysis:techniques for censored and truncated data, Survival analysis:Techniques for censorship and truncation data, کتابخانه مرکزی ایران.
Journal ArticleDOI
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.
Stephanie J. Lee,John P. Klein,Michael Haagenson,Lee Ann Baxter-Lowe,Dennis L. Confer,Mary Eapen,Marcelo Fernandez-Vina,Neal Flomenberg,Mary M. Horowitz,Carolyn Katovich Hurley,Harriet Noreen,Machteld Oudshoorn,Effie W. Petersdorf,Michelle Setterholm,Stephen R. Spellman,Daniel J. Weisdorf,Thomas M. Williams,Claudio Anasetti +17 more
TL;DR: In multivariate modeling, patient age, race, disease stage, and cytomegalovirus status were as predictive of survival as donor HLA matching, and high-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival.
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Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study
Brigitte Strahm,Peter Nöllke,Marco Zecca,E T Korthof,Marc Bierings,Ingrid Furlan,Petr Sedlacek,Alicja Chybicka,Markus Schmugge,Victoria Bordon,Christoph Peters,Aengus O'Marcaigh,C. D. De Heredia,Eva Bergstraesser,Barbara De Moerloose,M.M. van den Heuvel-Eibrink,J. Starý,M. Trebo,Dorota Wojcik,Charlotte M. Niemeyer,Francesco Locatelli +20 more