Journal ArticleDOI
Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group
Patrick Y. Wen,David R. Macdonald,David A. Reardon,Timothy F. Cloughesy,A. Gregory Sorensen,Evanthia Galanis,John DeGroot,Wolfgang Wick,Mark R. Gilbert,Andrew B. Lassman,Christina Tsien,Tom Mikkelsen,Eric T. Wong,Marc C. Chamberlain,Roger Stupp,Kathleen R. Lamborn,Michael A. Vogelbaum,Martin J. van den Bent,Susan M. Chang +18 more
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TLDR
The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies.Abstract:
Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only address the contrast-enhancing component of the tumor. For example, chemoradiotherapy for newly diagnosed glioblastomas results in transient increase in tumor enhancement (pseudoprogression) in 20% to 30% of patients, which is difficult to differentiate from true tumor progression. Antiangiogenic agents produce high radiographic response rates, as defined by a rapid decrease in contrast enhancement on CT/MRI that occurs within days of initiation of treatment and that is partly a result of reduced vascular permeability to contrast agents rather than a true antitumor effect. In addition, a subset of patients treated with antiangiogenic agents develop tumor recurrence characterized by an increase in the nonenhancing component depicted on T2-weighted/fluid-attenuated inversion recovery sequences. The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies. The Response Assessment in Neuro-Oncology Working Group is an international effort to develop new standardized response criteria for clinical trials in brain tumors. In this proposal, we present the recommendations for updated response criteria for high-grade gliomas.read more
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Journal ArticleDOI
Central nervous system gliomas
TL;DR: Evidence-based practical guidelines on diagnosis, prognosis, and treatment on the most frequent adult brain tumours are delineated and impaired neurocognitive and neuropsychological function is common in long-term survivors, regardless of the histology and grade of the tumour and should be taken into account in treatment planning.
Journal ArticleDOI
Automatic assessment of glioma burden: a deep learning algorithm for fully automated volumetric and bidimensional measurement.
Ken Chang,Andrew Beers,Harrison X. Bai,James M. Brown,K. Ina Ly,Xuejun Li,Joeky T. Senders,Vasileios K. Kavouridis,Alessandro Boaro,Chang Su,Wenya Linda Bi,Otto Rapalino,Weihua Liao,Qin Shen,Hao Zhou,Bo Xiao,Yinyan Wang,Paul J. Zhang,Marco C. Pinho,Patrick Y. Wen,Tracy T. Batchelor,Jerrold L. Boxerman,Omar Arnaout,Bruce R. Rosen,Elizabeth R. Gerstner,Li Yang,Raymond Y. Huang,Jayashree Kalpathy-Cramer +27 more
TL;DR: A deep learning algorithm that automatically segments abnormal fluid attenuated inversion recovery (FLAIR) hyperintensity and contrast-enhancing tumor, quantitating tumor volumes as well as the product of maximum bidimensional diameters according to the RANO criteria demonstrates potential utility for evaluating tumor burden in complex posttreatment settings.
Journal ArticleDOI
Dynamic-susceptibility contrast agent MRI measures of relative cerebral blood volume predict response to bevacizumab in recurrent high-grade glioma.
Kathleen M. Schmainda,Melissa Prah,Jennifer Connelly,Scott D. Rand,Raymond G. Hoffman,Wade M. Mueller,Mark G. Malkin +6 more
TL;DR: Standardized rCBV is predictive of overall survival (OS) and progression free survival (PFS) in patients with recurrent high-grade brain tumor treated with bevacizumab.
Journal ArticleDOI
Response Assessment in Neuro-Oncology
Eudocia C. Quant,Patrick Y. Wen +1 more
TL;DR: Current response criteria for high-grade glioma, low- grade gliomas, brain metastasis, meningioma), and schwannoma are reviewed.
Journal ArticleDOI
Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial
TL;DR: In this paper , the activity and safety of dabrafenib plus trametinib were evaluated in adult patients with recurrent or progressive BRAFV600E mutation-positive high-grade glioma and low-grade lgoma.
References
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
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Malignant Gliomas in Adults
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