Journal ArticleDOI
Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group
Patrick Y. Wen,David R. Macdonald,David A. Reardon,Timothy F. Cloughesy,A. Gregory Sorensen,Evanthia Galanis,John DeGroot,Wolfgang Wick,Mark R. Gilbert,Andrew B. Lassman,Christina Tsien,Tom Mikkelsen,Eric T. Wong,Marc C. Chamberlain,Roger Stupp,Kathleen R. Lamborn,Michael A. Vogelbaum,Martin J. van den Bent,Susan M. Chang +18 more
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TLDR
The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies.Abstract:
Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only address the contrast-enhancing component of the tumor. For example, chemoradiotherapy for newly diagnosed glioblastomas results in transient increase in tumor enhancement (pseudoprogression) in 20% to 30% of patients, which is difficult to differentiate from true tumor progression. Antiangiogenic agents produce high radiographic response rates, as defined by a rapid decrease in contrast enhancement on CT/MRI that occurs within days of initiation of treatment and that is partly a result of reduced vascular permeability to contrast agents rather than a true antitumor effect. In addition, a subset of patients treated with antiangiogenic agents develop tumor recurrence characterized by an increase in the nonenhancing component depicted on T2-weighted/fluid-attenuated inversion recovery sequences. The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies. The Response Assessment in Neuro-Oncology Working Group is an international effort to develop new standardized response criteria for clinical trials in brain tumors. In this proposal, we present the recommendations for updated response criteria for high-grade gliomas.read more
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Early response assessment of glioma patients to definitive chemoradiotherapy using chemical exchange saturation transfer imaging at 7 T.
Jan Eric Meissner,Andreas Korzowski,Sebastian Regnery,Steffen Goerke,Johannes Breitling,Johannes Breitling,Johannes Breitling,Ralf Floca,Jürgen Debus,Heinz Peter Schlemmer,Mark E. Ladd,Mark E. Ladd,Peter Bachert,Peter Bachert,Sebastian Adeberg,Daniel Paech +15 more
TL;DR: Patients with newly diagnosed inoperable glioma receive chemoradiotherapy (CRT) and standard Response Assessment in Neuro‐Oncology (RANO) takes a minimum of 4 weeks after the end of treatment.
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A Patch-Based Approach for the Segmentation of Pathologies: Application to Glioma Labelling
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Dexamethasone alleviates tumor-associated brain damage and angiogenesis.
TL;DR: Investigations reveal that DEXA acts pleiotropically and impacts tumor growth, tumor vasculature and tumor-associated brain damage, andDEXA executes neuroprotective effects in brains and reduces tumor-induced angiogenesis.
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Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab
Tali Siegal,Hanna Charbit,Iddo Paldor,Bracha Zelikovitch,Tamar Canello,Arriel Benis,Michael L. Wong,Andrew P. Morokoff,Andrew H. Kaye,Iris Lavon +9 more
TL;DR: Circulating levels ofmiR-10b and miR-21 probably reflect the antiangiogenic effect of therapy, but their role as biomarkers for tumor response remains uncertain and requires further investigation.
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An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors.
Martha R. Neagu,David A. Reardon +1 more
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
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Malignant Gliomas in Adults
Patrick Y. Wen,Santosh Kesari +1 more
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