Journal ArticleDOI
Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans
Asokumar Buvanendran,Jeffrey S. Kroin,Richard A. Berger,Nadim J. Hallab,Chiranjeev Saha,Corina Negrescu,Mario Moric,Marco S. Caicedo,Kenneth J. Tuman +8 more
TLDR
The results suggest that upregulation of prostaglandin E2 and interleukin 6 at central sites is an important component of surgery induced inflammatory response in patients and may influence clinical outcome.Abstract:
Background:The central and peripheral inflammatory response to surgery may influence patient outcomes. This study examines the time course and clinical relevance of changes in prostaglandin E2 and cytokines in cerebrospinal fluid, local tissue (surgical site), and circulating blood during and afterread more
Citations
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Resolving postoperative neuroinflammation and cognitive decline
Niccolò Terrando,Lars Eriksson,Lars Eriksson,Jae K. Ryu,Ting Yang,Claudia Monaco,Marc Feldmann,Malin Jonsson Fagerlund,Israel F. Charo,Katerina Akassoglou,Mervyn Maze +10 more
TL;DR: This work sought to understand the mechanisms whereby the brain is targeted by the inflammatory response and how this can be resolved.
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Multimodal analgesia for controlling acute postoperative pain.
TL;DR: There is a continuing need to explore new drug combinations to achieve all of the purported goals of multimodal anesthesia.
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Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
TL;DR: Cognitive function in splenectomized animals was impaired at days 1 and 3 after surgery compared with cognitive function in nonanesthetized rats, and splenectomy performed during neuroleptic anesthesia triggers a cognitive decline that is associated with a hippocampal inflammatory response that seems to be due to proinflammatory cytokine-dependent activation of glial cells.
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Exploiting the critical perioperative period to improve long-term cancer outcomes
TL;DR: The measures described in this Review could transform the perioperative timeframe from a prominent facilitator of metastatic progression, to a window of opportunity for arresting and/or eliminating residual disease, potentially improving long-term survival rates in patients with cancer.
Journal ArticleDOI
Persistent Postsurgical Pain: Pathophysiology and Preventative Pharmacologic Considerations.
TL;DR: Clinical investigations evaluating different preventative pharmacologic strategies that are routinely used by anesthesiologists in their daily clinical practices for preventing persistent postoperative pain are described.
References
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Journal ArticleDOI
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
TL;DR: Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from the current understanding of eicosanoid biology.
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Preemptive analgesia--treating postoperative pain by preventing the establishment of central sensitization.
Clifford J. Woolf,Mun-Seng Chong +1 more
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Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Tarek A. Samad,Kimberly A. Moore,Adam Sapirstein,Sara Billet,Andrew Allchorne,Stephen Poole,Joseph V. Bonventre,Clifford J. Woolf +7 more
TL;DR: Prostaglandin E2 levels in the cerebrospinal fluid are Elevated by finding a widespread induction of Cox-2 expression in spinal cord neurons and in other regions of the CNS, and preventing central prostanoid production by inhibiting the interleukin-1β-mediated induction ofcox-2 in neurons reduces centrally generated inflammatory pain hypersensitivity.
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Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty.
TL;DR: The maintenance of intraoperative normothermia reduces blood loss and allogeneic blood requirements in patients undergoing total hip arthroplasty and increases blood loss in the hypothermic patients.
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Response of serum interleukin-6 in patients undergoing elective surgery of varying severity.
TL;DR: The results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis, and it is concluded that seruminterleuk in-6 is a sensitive, early marker of tissue damage.