Journal ArticleDOI
Urinary free Cortisol excretion in depression
TLDR
Depressed patients who had high daily UFC values and those with depressive neuroses excreted less than unipolar or bipolar depressives and following treatment, more normal UFC excretion was found in depressed patients.Abstract:
Urinary free Cortisol (UFC) excretion was determined in 60 depressed inpatients and in 35 psychiatric inpatients with other disorders. The depressed patients had high daily UFC values, while the other patients excreted normal amounts. Over 40% of the depressed patients had UFC excretions in the range seen in Cushing's disease, while only 6% of the other patients excreted such high amounts of Cortisol. Age and sex differences did not account for the results. Among the depressed patients those with depressive neuroses excreted less than unipolar or bipolar depressives. Following treatment, more normal UFC excretion was found in depressed patients. The estimation of UFC and its clinical utility are discussed in detail. UFC determination is a simple and informative indicator of adrenal cortical activation and its application to psychoendocrine studies is recommended.read more
Citations
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Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy.
TL;DR: Suggestions to improve the assessment of behavioral interventions include more complete delineation of the physiological mechanisms by which such interventions might work; increased use of new, more convenient "alternative" end points for behavioral intervention trials; development of specifically targeted behavioral interventions (based on profiling of patient factors); and evaluation of previously developed models of predicting behavioral change.
Journal ArticleDOI
Hippocampal volume reduction in major depression.
J. Douglas Bremner,Meena Narayan,Eric R. Anderson,Lawrence H. Staib,Helen L. Miller,Dennis S. Charney +5 more
TL;DR: These findings are consistent with smaller left hippocampal volume in depression, and were significant after brain size, alcohol exposure, age, and education were controlled for.
Journal ArticleDOI
Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients
Charles B. Nemeroff,Erik Widerlöv,Garth Bissette,Helena Walleus,Ingvar Karlsson,Kurt Eklund,Clinton D. Kilts,Peter T. Loosen,Wylie Vale +8 more
TL;DR: Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.
Journal ArticleDOI
Cushing's syndrome
TL;DR: The current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches, and diagnostic algorithms and recommendations for management of Cushing's syndrome are reviewed.
Journal ArticleDOI
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
TL;DR: A meta-analysis of studies that used magnetic resonance imaging to assess the volume of the hippocampus and related structures in patients with major depressive disorder found inclusion of the amygdala with the hippocampus appears to have decreased the likelihood of detecting volumetric differences in either structure.
References
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Journal ArticleDOI
Cortisol Is Secreted Episodically by Normal Man
Leon Hellman,Fujinori Nakada,Joseph Curti,Elliot D. Weitzman,Jacob Kream,Howard P. Roffwarg,Steven Ellman,David K. Fukushima,T. F. Gallagher +8 more
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