Journal ArticleDOI
Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis.
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TLDR
A fundamental difference between macrophages and hepatocytes in terms of cholesterol homeostasis is demonstrated, and an important role for UII in modulating cholesterol regulation is suggested.About:
This article is published in Peptides.The article was published on 2011-05-01. It has received 19 citations till now. The article focuses on the topics: Cholesteryl ester & Urotensin-II.read more
Citations
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Journal ArticleDOI
Genetic and Pharmacological Manipulation of Urotensin II Ameliorate the Metabolic and Atherosclerosis Sequalae in Mice
Zhipeng You,Jacques Genest,Pierre-Olivier Barrette,Anouar Hafiane,David J. Behm,Pedro D'Orléans-Juste,Adel Schwertani +6 more
TL;DR: It is suggested that the use of pharmaceutical agents aimed at blocking the UII pathway may provide a novel approach in the treatment of atherosclerosis and its associated precursors such as obesity, hyperlipidemia, diabetes mellitus, and hypertension.
Journal ArticleDOI
Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.
Dong-yu Liang,Liang-ming Liu,Chang-gen Ye,Liang Zhao,Fang-ping Yu,De-Yong Gao,Yingying Wang,Zhi‐wen Yang,Yan-yan Wang +8 more
TL;DR: Urantide has a protective effect on the acutely inflamed injury of liver in part through preventing releases of proinflammatory cytokines and activation of NF-κB pathway.
Journal ArticleDOI
Hepatic Cholesterol Homeostasis Is the Low-Density Lipoprotein Pathway a Regulatory or a Shunt Pathway?
Allan D. Sniderman,Yanqin Qi,Cheng-I J. Ma,Rui Hao Leo Wang,Mark Naples,Christopher A. Baker,Jing Zhang,Khosrow Adeli,Robert S. Kiss +8 more
TL;DR: In this paper, the effects of cholesterol that enters the hepatocyte within an LDL particle with those of LDL that enters via other lipoprotein particles were compared to other sources, including chylomicron remnants.
A closer look at the role of urotensin II in the metabolic
TL;DR: Urotensin II (UII) is a vasoactive peptide that was first discovered in the teleost fish and later in mammals and humans as mentioned in this paper, and it mediates important physiological and pathological actions by interacting with its receptor.
Journal ArticleDOI
Tweaking the cholesterol efflux capacity of reconstituted HDL
Cheng-I J. Ma,Jennifer A. Beckstead,Airlia Thompson,Anouar Hafiane,Rui Hao Leo Wang,Robert O. Ryan,Robert S. Kiss +6 more
TL;DR: The data show that cholesterol efflux activity is dependent upon the apoA-I protein employed, as well as the phospholipid constituent of the r HDL, and future studies designed to optimize the efflux capacity of therapeutic rHDL may improve the value of this emerging intervention strategy.
References
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Journal ArticleDOI
The LDL Receptor
TL;DR: The history of the LDL receptor is recounted by its codiscoverers to explain a genetic cause of heart attacks and introduce three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors.
Journal ArticleDOI
Acyl-coenzyme a:cholesterol acyltransferase
TL;DR: This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) AC AT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
Journal ArticleDOI
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Robert S. Ames,Henry M. Sarau,Johathan K. Chambers,Robert N. Willette,Nambi Aiyar,Anne M. Romanic,Calvert Louden,James J. Foley,Charles F. Sauermelch,Robert W. Coatney,Zhaohui Ao,Jyoti Disa,Stephen Dudley Holmes,Jeffrey M. Stadel,John D. Martin,Wu-Schyong Liu,George I. Glover,Shelagh Wilson,Dean E. McNulty,Catherine E. Ellis,Nabil Elshourbagy,Usman Shabon,John J. Trill,Douglas W. P. Hay,Eliot H. Ohlstein,Derk J. Bergsma,Stephen A. Douglas +26 more
TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.
Journal ArticleDOI
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
TL;DR: A review of the major milestones in the cholesterol feedback story can be found in this paper, where the authors discuss the role of sterol regulatory element-binding proteins (SREBPs) in cholesterol biosynthesis.
Journal ArticleDOI
Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
David Pearson,John E. Shively,Brian R. Clark,Irving I. Geschwind,Marylynn Barkley,Richard S. Nishioka,Howard A. Bern +6 more
TL;DR: Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC) to establish its structure.
Related Papers (5)
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Robert S. Ames,Henry M. Sarau,Johathan K. Chambers,Robert N. Willette,Nambi Aiyar,Anne M. Romanic,Calvert Louden,James J. Foley,Charles F. Sauermelch,Robert W. Coatney,Zhaohui Ao,Jyoti Disa,Stephen Dudley Holmes,Jeffrey M. Stadel,John D. Martin,Wu-Schyong Liu,George I. Glover,Shelagh Wilson,Dean E. McNulty,Catherine E. Ellis,Nabil Elshourbagy,Usman Shabon,John J. Trill,Douglas W. P. Hay,Eliot H. Ohlstein,Derk J. Bergsma,Stephen A. Douglas +26 more