Journal ArticleDOI
Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: stability testing of selected solid dispersions.
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TLDR
By and large, the surfactants appear to be promising plasticizers to produce solid dispersions by hot melt extrusion, in so doing improving dissolution rate without compromising the physical stability of the systems.Abstract:
Purpose
The purpose of the study is to evaluate the effect of surfactant-plasticizers on the physical stability of amorphous drug in polymer matrices formed by hot melt extrusion.read more
Citations
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Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs
TL;DR: This review attempts to address the critical molecular and thermodynamic aspects governing the physicochemical properties of amorphous solid dispersion systems and potential advantage of polymers as inert, hydrophilic, pharmaceutical carrier matrices.
Journal ArticleDOI
Progress in bio-based plastics and plasticizing modifications
TL;DR: A review of the most common bio-based polymeric materials can be found in this paper, which provides an overview of recent advances in the selection and use of plasticizers, and their effect on the performance of these materials.
Journal ArticleDOI
Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State
Chandan Bhugra,Michael J. Pikal +1 more
TL;DR: An increased understanding of the relative contributions of molecular mobility and processing conditions are vital to increased usage of the amorphous state in solid oral dosage forms.
Journal ArticleDOI
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation
TL;DR: This review discussed the importance of using the quality by design approach in drug development, evaluated the process analytical technology used in pharmaceutical HME monitoring and control, discussed techniques used in HME, and emphasized the potential for monitoring and controlling hot-melt technology.
References
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Journal ArticleDOI
From molecules to crystal engineering: supramolecular isomerism and polymorphism in network solids.
Journal ArticleDOI
Graph-set analysis of hydrogen-bond patterns in organic crystals
TL;DR: A method is presented based on graph theory for categorizing hydrogen-bond motifs in such a way that complex hydrogen- bond patterns can be disentangled, or decoded, systematically and consistently.
Journal ArticleDOI
The mechanisms of drug release from solid dispersions in water-soluble polymers.
TL;DR: A model is proposed whereby the release behaviour from the dispersions may be understood in terms of the dissolution or otherwise of the drug into the concentrated aqueous polymer layer adjacent to the solid surface, including a derivation of an expression to describe the release of intact particles from the dispersed particles.
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General principles of pharmaceutical solid polymorphism: a supramolecular perspective.
Barbara Rodríguez-Spong,Christopher P. Price,Adivaraha Jayasankar,Adam J. Matzger,Naír Rodríguez-Hornedo +4 more
TL;DR: Current understanding of pharmaceutical solids in terms of molecular recognition and complementarity provides new insights into the design and function of single and fully miscible, multiple-component solids with varying degrees of order, and in this way is leading the path to supramolecular pharmaceutics.
Journal ArticleDOI
Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer-surfactant combinations using solubility parameters and testing the processability.
TL;DR: Thermal analysis of the API-polymer-surfactant blends suggested that the surfactants caused solvation/plasticization, manifesting in reduction of the melting of API and T(m) of polymers and the combined T(g) of the solid dispersion formed from quench cooling.