Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
Sonia S. Hassan,Sonia S. Hassan,Roberto Romero,Roberto Romero,Roberto Romero,D. Vidyadhari,S. Fusey,Jason K. Baxter,Meena Khandelwal,J. Vijayaraghavan,Y. Trivedi,Priya Soma-Pillay,P. Sambarey,Ashlesha K. Dayal,V. Potapov,John M. O'Brien,John M. O'Brien,V. Astakhov,O. Yuzko,W. Kinzler,B. Dattel,H. Sehdev,L. Mazheika,D. Manchulenko,M. T. Gervasi,Lisa M. Sullivan,Agustin Conde-Agudelo,James A. Phillips,George W. Creasy +28 more
TLDR
The efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix is determined.Abstract:
Objectives Women with a sonographic short cervix in the mid-trimester are at increased risk for preterm delivery. This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix. Methods This was a multicenter, randomized, doubleblind, placebo-controlled trial that enrolled asymptomaticread more
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Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data
Roberto Romero,Kypros H. Nicolaides,Agustin Conde-Agudelo,Ann Tabor,Ann Tabor,John M. O'Brien,Elcin Cetingoz,Eduardo Ribeiro da Fonseca,George W. Creasy,Katharina Klein,Line Rode,Priya Soma-Pillay,Shalini Fusey,Cetin Cam,Zarko Alfirevic,Sonia S. Hassan,Sonia S. Hassan +16 more
TL;DR: Vaginal progesterone administration to asymptomatic women with a sonographic short cervix in the midtrimester reduces the risk of preterm birth and neonatal morbidity and mortality.
Journal ArticleDOI
Immune cells in term and preterm labor
Nardhy Gomez-Lopez,Derek StLouis,Marcus A Lehr,Elly N. Sanchez-Rodriguez,Marcia Arenas-Hernandez +4 more
TL;DR: A balance between innate and adaptive immune cells is required in order to sustain pregnancy; an alteration of this balance will lead to labor at term or preterm.
Journal ArticleDOI
Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial
Jane E. Norman,Neil Marlow,Claudia-Martina Messow,Andrew Shennan,Phillip R. Bennett,Steven Thornton,Stephen C. Robson,Alex McConnachie,Stavros Petrou,Neil J. Sebire,Tina Lavender,Sonia Whyte,John Norrie +12 more
TL;DR: Vaginal progesterone was not associated with reduced risk of preterm birth or composite neonatal adverse outcomes, and had no long-term benefit or harm on outcomes in children at 2 years of age.
Journal ArticleDOI
Vaginal Progesterone for Preventing Preterm Birth and Adverse Perinatal Outcomes in Singleton Gestations with a Short Cervix: A Meta-Analysis of Individual Patient Data
Roberto Romero,Agustin Conde-Agudelo,Eduardo Ribeiro da Fonseca,John M. O'Brien,Elcin Cetingoz,George W. Creasy,Sonia S. Hassan,Kypros H. Nicolaides +7 more
TL;DR: Vaginal progesterone decreases the risk of preterm birth and improves perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix, without any demonstrable deleterious effects on childhood neurodevelopment.
Journal ArticleDOI
Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth
TL;DR: The benefits and harms of progesterone for the prevention of preterm birth for women considered to be at increased risk of pre term birth and their infants are assessed.
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