Journal ArticleDOI
Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model
P. Pratheesh Kumar,Girija Kuttan +1 more
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Vernonia cinerea extract significantly inhibited carrageenan induced inflammation, compared with control models and down regulation of pro-inflammatory cytokine level and gene expression were also support the above result.Abstract:
In this study, we evaluated the anti-oxidant and anti-inflammatory activities of the medicinal plant, Vernonia cinerea L (Asteraceae) using in vitro as well as in vivo models. Methanolic extract of Vernonia cinerea was found to scavenge the hydroxyl radical generated by Fenton reaction (IC(50)130 microg/ml), Superoxide generated by photo reduction of riboflavin (IC(50)190 microg/ml) and inhibited lipid peroxidation significantly (IC(50)130.5 microg/ml). The drug also scavenged nitric oxide (IC(50)210 microg/ml). Intraperitoneal administration of Vernonia cinerea was found to inhibit the PMA induced Superoxide generation in mice peritoneal macrophages. The administration of Vernonia cinerea to mice significantly increased the levels of catalase, superoxide dismutase, glutathione, glutathione peroxidase and glutathione-S transferase in blood and liver, whereas lipid peroxidation activity was significantly decreased. It was also found that Vernonia cinerea extract significantly inhibited carrageenan induced inflammation, compared with control models. Down regulation of pro-inflammatory cytokine level and gene expression were also support the above result.read more
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Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Bharat B. Aggarwal,Sahdeo Prasad,Simone Reuter,Ramaswamy Kannappan,Vivek R. Yadav,Byoungduck Park,Ji Hye Kim,Subash C. Gupta,Kanokkarn Phromnoi,Chitra Sundaram,Seema Prasad,Madan M. Chaturvedi,Bokyung Sung +12 more
TL;DR: Ayurveda, a science of long life, almost 6,000 years old, can serve as a "goldmine" for novel anti-inflammatory agents used for centuries to treat chronic diseases, and description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit are provided.
Journal ArticleDOI
A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae).
Ngeh J. Toyang,Robert Verpoorte +1 more
TL;DR: Vernolide A is so far the most promising single agent from a Vernonia species that has potential for development into an anticancer agent and Vernonia amygdalina was identified as the most frequently used member of the Vernonia genus.
Journal ArticleDOI
Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress.
Renan O. Silva,Francisca Beatriz M. Sousa,Samara R.B. Damasceno,Nathalia S. Carvalho,Valdelânia G Silva,Francisco Rodrigo M.A. Oliveira,Damião Pergentino de Sousa,Karoline S. Aragão,André Luiz dos Reis Barbosa,Rivelilson Mendes de Freitas,Jand Venes R. Medeiros +10 more
TL;DR: The results suggest that phytol attenuates the inflammatory response by inhibiting neutrophil migration that is partly caused by reduction in IL‐1β and TNF‐α levels and oxidative stress.
Journal ArticleDOI
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.
Poyil Pratheeshkumar,Young-Ok Son,Sasidharan Padmaja Divya,Ram Vinod Roy,John Andrew Hitron,Lei Wang,Donghern Kim,Jin Dai,Padmaja Asha,Zhuo Zhang,Yitao Wang,Xianglin Shi +11 more
TL;DR: The results indicate that luteolin protects BEAS-2B cells from Cr(VI)-induced carcinogenesis by scavenging ROS and modulating multiple cell signaling mechanisms that are linked to ROS.
Journal ArticleDOI
Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract.
Ming Hsing Huang,Bor Sen Wang,Chuan Sung Chiu,Chuan Sung Chiu,Sakae Amagaya,Wen Tsong Hsieh,Shyh-Shyun Huang,Pei Hsin Shie,Guan-Jhong Huang +8 more
TL;DR: In this article, aqueous extract of Xanthii fructus (AXF) was evaluated in mice for anti-inflammatory activity using carrageenan-induced hind paw edema model.
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