Journal ArticleDOI
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
TLDR
An adoptive transfer system was used to monitor physically the behavior of a trace population of TCR transgenic T cells in vivo, providing a physical basis for the classical finding that antigen-specific memory and tolerance can be influenced by the form of antigen administration.About:
This article is published in Immunity.The article was published on 1994-07-01. It has received 991 citations till now. The article focuses on the topics: Peripheral tolerance induction & Immune tolerance.read more
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Journal ArticleDOI
Tolerogenic dendritic cells.
TL;DR: It is suggested that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
Journal ArticleDOI
Lymphocyte homing and homeostasis.
TL;DR: A review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.
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Cd28/b7 system of t cell costimulation
TL;DR: This review summarizes the state of CD28/B7 immunobiology both in vitro and in vivo; summarizes the many experiments that have led to the current understanding of the participants in this complex receptor/ligand system; and illustrates the current models for CD28-mediated T cell and B cell regulation.
Journal ArticleDOI
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
Daniel Hawiger,Kayo Inaba,Kayo Inaba,Yair Dorsett,Ming Guo,Karsten Mahnke,Miguel Rivera,Jeffrey V. Ravetch,Ralph M. Steinman,Michel C. Nussenzweig,Michel C. Nussenzweig +10 more
TL;DR: An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
Journal ArticleDOI
Immunological Memory and Protective Immunity: Understanding Their Relation
Rafi Ahmed,David Gray +1 more
TL;DR: The current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.
References
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Journal ArticleDOI
The dendritic cell system and its role in immunogenicity
TL;DR: Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
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Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
TL;DR: Results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance in mice transgenic for a T cell receptor that reacts to this peptide.
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The immune system evolved to discriminate infectious nonself from noninfectious self
TL;DR: It is argued that the requirement for two signals to initiate the adaptive immune response may reflect the evolutionary history of host defences.
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Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
Peter S. Linsley,William E. Brady,Laura Sue Grosmaire,Alejandro Aruffo,Nitin K. Damle,Jeffrey A. Ledbetter +5 more
TL;DR: It is demonstrated that the CD28 signaling pathway could be activated by B7, resulting in increased T cell cytokine production and T cell proliferation, and costimulatory for T cell activation.
Journal ArticleDOI
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.
TL;DR: The results suggest that nonmitogenic T cell recognition of antigen/MHC on ECDI-modified APCs results in the functional inactivation of T cell clones.