Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study
Thomas A. Wadden,Priscilla Hollander,S Klein,Kevin D. Niswender,V Woo,P M Hale,Louis J. Aronne +6 more
TLDR
Liraglutide, with diet and exercise, maintained weight loss achieved by caloric restriction and induced further weight loss over 56 weeks, and produced small but statistically significant improvements in several cardiometabolic risk factors compared with placebo.Abstract:
Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized studyread more
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A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
Xavier Pi-Sunyer,Arne Astrup,Ken Fujioka,Frank L. Greenway,Alfredo Halpern,Michel Krempf,David C.W. Lau,Carel W. le Roux,Rafael Violante Ortiz,Christine B. Jensen,John P.H. Wilding +10 more
TL;DR: 3.0 mg of liraglutide, as an adjunct to diet and exercise, was associated with reduced body weight and improved metabolic control in patients with type 2 diabetes and prediabetes.
Journal ArticleDOI
European Guidelines for Obesity Management in Adults
Volkan Yumuk,Constantine Tsigos,Martin Fried,Karin Schindler,Luca Busetto,Dragan Micic,Hermann Toplak +6 more
TL;DR: It is concluded that physicians have a responsibility to recognise obesity as a disease and help obese patients with appropriate prevention and treatment and focus on realistic goals and lifelong multidisciplinary management.
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American association of clinical endocrinologists and american college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity.
W. Timothy Garvey,Jeffrey I. Mechanick,Elise M. Brett,Alan J. Garber,Daniel L. Hurley,Ania M. Jastreboff,Karl Nadolsky,Rachel Pessah-Pollack,Raymond A Plodkowski +8 more
TL;DR: The final recommendations recognize that obesity is a complex, adiposity-based chronic disease, where management targets both weight-related complications and adiposity to improve overall health and quality of life.
Journal ArticleDOI
Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline
Caroline M. Apovian,Louis J. Aronne,Daniel H. Bessesen,Marie E. McDonnell,M. Hassan Murad,Uberto Pagotto,Donna H. Ryan,Christopher D. Still +7 more
TL;DR: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence.
Journal ArticleDOI
Long-term Drug Treatment for Obesity: A Systematic and Clinical Review
TL;DR: A systematic review of medications currently approved in the United States for obesity treatment in adults found that medications approved for long-term obesity treatment, when used as an adjunct to lifestyle intervention, lead to greater mean weight loss and an increased likelihood of achieving clinically meaningful 1-year weight loss relative to placebo.
References
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Journal ArticleDOI
The PHQ-9: validity of a brief depression severity measure.
TL;DR: In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity, which makes it a useful clinical and research tool.
Journal ArticleDOI
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
Obesity : Preventing and managing the global epidemic
D. S. Akram,Arne Astrup,T. Atinmo,J. L. Boissin,George A. Bray,K. Carroll,P. Chitson,C. Chunming,William H. Dietz,James O. Hill,Eric Jéquier,C. Komodiki,Yuji Matsuzawa,W. F. Mollentze,K. Moosa,M.I. Noor,K.S. Reddy,Jacob C. Seidell,V. Tanphaichitr,Ricardo Uauy,Paul Zimmet +20 more
Book ChapterDOI
World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects
TL;DR: Comparing the socialist nature of many European counties, there is a requirement that provision be made for patients to be made whole regardless of the outcomes of the trial or if they happened to have been randomized to a control group that did not enjoy the benefits of a successful experimental intervention.