Journal ArticleDOI
Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell
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TLDR
It is proposed that ROS‐induced pore opening lowers ROS production due to maximal stimulation of mitochondrial O2 consumption and, hence, intracellular [O2] lowering and (b) complete dissipation of mitochondrial membrane potentials and, as a consequence, maximal oxidation of such respiratory chain carriers as CoQ.About:
This article is published in FEBS Letters.The article was published on 1996-11-11. It has received 383 citations till now. The article focuses on the topics: Mitochondrial permeability transition pore & Mitochondrial membrane transport protein.read more
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Mitochondria and Neuronal Survival
TL;DR: The functional bioenergetics of isolated mitochondria are reviewed, with emphasis on the chemiosmotic proton circuit and the application (and occasional misapplication) of these principles to intact neurons.
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JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
TL;DR: Data indicate that JC‐1 is a reliable probe for analyzing ΔΨ changes with flow cytometry, while the others show a lower sensitivity (R123), or a non‐coherent behaviour, due to a high sensitivity to changes in plasmamembrane potential [DiOC6(3].
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Mitochondrial reactive oxygen species in cell death signaling.
TL;DR: In agreement with this role of ROS in apoptosis signaling, inhibition of apoptosis by anti-apoptotic Bcl-2 and BCl-x(L) is associated with a protection against ROS and/or a shift of the cellular redox potential to a more reduced state.
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Role of ROS and RNS Sources in Physiological and Pathological Conditions
TL;DR: The most recent data, besides confirming the mitochondrial role in tissue oxidative stress and protection, show interplay between mitochondria and other ROS cellular sources, so that activation of one can lead to activation of other sources.
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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
Alberto Boveris,Britton Chance +1 more
TL;DR: It is postulated that in addition to the well-known flavin reaction, formation of H( 2)O(2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level.
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Mitochondrial control of nuclear apoptosis
Naoufal Zamzami,Santos A. Susin,Philippe Marchetti,Tamara Hirsch,I. Gomez-Monterrey,Maria Castedo,Guido Kroemer +6 more
TL;DR: Direct evidence is presented indicating that mitochondrial PT constitutes a critical early event of the apoptotic process, and a specific ligand of the mitochondrial adenine nucleotide translocator, bongkreik acid, inhibits PT and reduces apoptosis induction by mitochondria in a cell-free system.
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Biogenesis of Mitochondria
TL;DR: The MITOCHONDRIAL GENETIC SYSTEM, a chronology of key events and events leading to and after the invention of the mitochondria, is described.
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Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
TL;DR: In this article, a concept is put forward that non-phosphorylating (uncoupled or non-coupled) respiration takes part in maintenance of low levels of both O2 and the O2 reductants when the normal respiration fails to do this job due to lack of ADP.