Journal ArticleDOI
Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach.
Raghul Murugan,R. Rajesh,Boopathi Seenivasan,B. Haridevamuthu,Gokul Sudhakaran,Ajay Guru,R. Rajakrishnan,Palaniselvam Kuppusamy,A Benitta juliet,Pushparathinam Gopinath,Jesu Arockiaraj +10 more
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TLDR
In this paper , the antibacterial activity of Withaferin A extracted from the traditional herb, ashwagandha or winter cherry (Withania somnifera) was demonstrated.About:
This article is published in Microbial Pathogenesis.The article was published on 2022-09-01. It has received 12 citations till now. The article focuses on the topics: Medicine & Withaferin A.read more
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Phytochemicals as Invaluable Sources of Potent Antimicrobial Agents to Combat Antibiotic Resistance
Ragi Jadimurthy,Swamy Jagadish,S. C. Nayak,Sumana Kumar,Chakrabhavi Dhananjaya Mohan,Kanchugarakoppal S. Rangappa +5 more
TL;DR: In this paper , the authors have discussed the importance of plant metabolites in the context of their medicinal applications and elaborated on their mechanism of antimicrobial action against human pathogens, including bacteria, fungi, and viruses.
Journal ArticleDOI
Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
Marta Malinowska,Joanna Nowak,Eliza Judasz,Gabriela Kaczmarek,Magdalena Paczkowska-Walendowska,Anna Gościniak,Judyta Cielecka-Piontek +6 more
TL;DR: Ashwagandha has been extensively studied in the literature as mentioned in this paper , including neuroprotective, sedative and adaptogenic effects and effects on sleep, and there are also reports of anti-inflammatory, antimicrobial, cardioprotective and anti-diabetic properties.
Journal ArticleDOI
Hepatoprotective effect of dihydroxy piperlongumine in high cholesterol-induced non-alcoholic fatty liver disease zebrafish via antioxidant activity.
B. Haridevamuthu,Boopathi Seenivasan,Patil Priya,Subramani Muthuraman,Rajendran Saravana Kumar,K. Manikanadan,Bader Almutairi,Mikhlid Almutairi,Selvaraj Arokiyaraj,Pushparathinam Gopinath,Jesu Arockiaraj +10 more
TL;DR: Wang et al. as discussed by the authors found dihydroxy piperlongumine (DHPL) possesses high antioxidant activity among the hydroxy piper longumines, which makes us curious to reveal the anti-NAFLD effect.
Journal ArticleDOI
Withania somnifera L.: Phenolic Compounds Composition and Biological Activity of Commercial Samples and Its Aqueous and Hydromethanolic Extracts
Milena Polumackanycz,Spyridon A. Petropoulos,Tomasz Sledzinski,Elzbieta Goyke,Agnieszka Konopacka,Alina Plenis,Agnieszka Viapiana +6 more
TL;DR: In this paper , the chemical composition and bioactive properties of commercially available Withania somnifera samples were evaluated in terms of phenolic compound composition, ascorbic acid content, antioxidant and antibacterial activity.
Journal ArticleDOI
PS9, Derived from an Aquatic Fungus Virulent Protein, Glycosyl Hydrolase, Arrests MCF-7 Proliferation by Regulating Intracellular Reactive Oxygen Species and Apoptotic Pathways
Manikandan Velayutham,Purabi Sarkar,Kanchana Karuppiah,Priyadharsan Arumugam,Shanavas Shajahan,Mohammad Abu Haija,Tansir Ahamad,Mariadhas Valan Arasu,Naif Abdullah Al-Dhabi,Ki Choon Choi,Ajay Guru,Jesu Arockiaraj +11 more
TL;DR: In this article , a short peptide, PS9, derived from a virulent protein, glycosyl hydrolase, of an aquatic fungus, Aphanomyces invadans, was used to arrest MCF-7 proliferation by regulating intercellular reactive oxygen species and apoptotic pathways.
References
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Reactive Oxygen Species in Inflammation and Tissue Injury
TL;DR: The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury.
Journal ArticleDOI
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.
David J. Newman,Gordon M. Cragg +1 more
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Lianjiu Su,Jiahao Zhang,Hernando Gomez,Raghavan Murugan,Xing Hong,Dongxue Xu,Fan Jiang,Zhiyong Peng,Zhiyong Peng +8 more
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Broad-spectrum antibacterial activity of carbon nanotubes to human gut bacteria.
Hanqing Chen,Bing Wang,Di Gao,Ming Guan,Lingna Zheng,Hong Ouyang,Zhifang Chai,Yuliang Zhao,Weiyue Feng +8 more
TL;DR: CNTs may be broad-spectrum and efficient antibacterial agents in the gut, and selective application of CNTs could reduce the potential hazard to probiotic bacteria.
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Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation.
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TL;DR: If the drug can be delivered efficiently to the inflammatory site, SOD may be useful as an inhibitory mediator of neutrophil-mediated inflammation and potentially useful as a therapeutic agent for treatment of inflammatory disorders.
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