Journal ArticleDOI
Wnt/Ca2+ signaling pathway: a brief overview
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TLDR
This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.Abstract:
The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca(2+) signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca(2+) pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.read more
Citations
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Dissertation
The role of canonical and non-canonical WNT signalling pathways in load induced cartilage degradation.
TL;DR: The differential expression of WNT signalling components in response to different mechanical load regimes indicates a role for these components in maintaining cartilage homeostasis.
Journal ArticleDOI
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Dong Zhou,Yuanyuan Wang,Yuan Gui,Haiyan Fu,Shan Shan Zhou,Yanlin Wang,Sheldon I. Bastacky,Donna B. Stolz,You-ju Liu +8 more
TL;DR: In this article , a cargo receptor protein required for Wnt secretion, was specifically deleted in glomerular podocytes, which resulted in upregulation of β-catenin, accompanied by reduction of nephrin, podocin, podocalyxin, and Wilms tumor 1 proteins.
Book ChapterDOI
WNT Signaling Is a Key Player in Alzheimer's Disease.
TL;DR: The role of WNT in the adult central nervous system has been the focus of interest in our laboratory as discussed by the authors, and the WNT pathway is therefore positioned as a therapeutic target for AD and could be a valid concept for improving AD therapy.
Journal ArticleDOI
Roles of Wnt/β-catenin signaling pathway related microRNAs in esophageal cancer
TL;DR: The interaction between miRNAs and the Wnt/β-catenin signaling pathway, which is specifically expressed in esophageal cancer tissues, shows potential as a new biomarker and therapeutic target.
References
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Journal ArticleDOI
The fundamental role of epigenetic events in cancer
Peter A. Jones,Stephen B. Baylin +1 more
TL;DR: This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.
Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
Journal ArticleDOI
Wnt proteins are lipid-modified and can act as stem cell growth factors
Karl Willert,Jeffrey Brown,Esther Danenberg,Andrew W. Duncan,Irving L. Weissman,Tannishtha Reya,John R. Yates,Roel Nusse +7 more
TL;DR: This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
Journal ArticleDOI
Transcriptional regulation by calcium, calcineurin, and NFAT
TL;DR: The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response.