Journal ArticleDOI
Wnt/Ca2+ signaling pathway: a brief overview
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TLDR
This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.Abstract:
The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca(2+) signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca(2+) pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.read more
Citations
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Book ChapterDOI
Wnt Pathway at a Glance: From the Deep of the Crypts to the Current Ways of Targeting
Antonio Barbáchano,María Jesús Larriba,Gemma Ferrer-Mayorga,Alberto Muñoz,José Manuel González-Sancho +4 more
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CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development
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A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury
TL;DR: In this paper, the effects of Ginkgolide B (GB) on the Glu transporter and Glu-induced apoptosis of astrocytes were studied by RT-qPCR and western blot.
Book ChapterDOI
Nonconventional axon guidance cues: Hedgehog, TGF-β/BMP, and Wnts in axon guidance
Patricia T. Yam,Frédéric Charron +1 more
TL;DR: In addition to directly guiding axons, some nonconventional guidance cues modulate the response of axons to other guidance cues, adding another level of complexity to axon pathfinding mechanisms.
References
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Journal ArticleDOI
Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
Journal ArticleDOI
Wnt proteins are lipid-modified and can act as stem cell growth factors
Karl Willert,Jeffrey Brown,Esther Danenberg,Andrew W. Duncan,Irving L. Weissman,Tannishtha Reya,John R. Yates,Roel Nusse +7 more
TL;DR: This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
Journal ArticleDOI
Transcriptional regulation by calcium, calcineurin, and NFAT
TL;DR: The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response.