Journal ArticleDOI
Wnt/Ca2+ signaling pathway: a brief overview
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TLDR
This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.Abstract:
The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca(2+) signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca(2+) pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.read more
Citations
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Wnt signaling in cancer.
TL;DR: Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control are described.
Journal ArticleDOI
The complex world of WNT receptor signalling
TL;DR: What emerges is an intricate network of receptors that form higher-order ligand–receptor complexes routing downstream signalling that is regulated both extracellularly by agonists such as R-spondin and intracellulary by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis.
Journal ArticleDOI
Osteoimmunomodulation for the development of advanced bone biomaterials
Zetao Chen,Travis J. Klein,Rachael Z. Murray,Ross Crawford,Jiang Chang,Jiang Chang,Chengtie Wu,Chengtie Wu,Yin Xiao +8 more
TL;DR: In this article, the importance of the immune response during biomaterial-mediated osteogenesis was recognized and the paradigm shift of bone biomaterials to an osteo-immunomodulatory material was proposed.
Journal ArticleDOI
The soft agar colony formation assay.
Stanley Borowicz,Michelle Van Scoyk,Sreedevi Avasarala,Manoj Kumar Karuppusamy Rathinam,Jordi Tauler,Rama Kamesh Bikkavilli,Robert A. Winn,Robert A. Winn +7 more
TL;DR: The soft agar colony formation assay shows that expression of Wnt7a ligand and its Frizzled-9 receptor is sufficient to suppress tumor growth in a murine lung carcinoma model.
Journal ArticleDOI
Wnt signaling in bone formation and its therapeutic potential for bone diseases
Jeong Hwan Kim,Xing Liu,Jinhua Wang,Xiang Chen,Hongyu Zhang,Stephanie H. Kim,Jing Cui,Ruidong Li,Wenwen Zhang,Yuhan Kong,Jiye Zhang,Wei Shui,Joseph D. Lamplot,Mary Rose Rogers,Chen Zhao,Ning Wang,Prashant Rajan,Justin Tomal,Joseph Statz,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He +22 more
TL;DR: The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential and indicates it requires cautious approach due to risks of tumorigenesis.
References
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Journal ArticleDOI
Low expression of Wnt-5a gene is associated with high-risk neuroblastoma.
TL;DR: This study highlights, for the first time, the involvement of Wnt-5a, which has a role in embryonic and morphogenetic processes, in the response of malignant neuroblasts to RA, and demonstrates that RA, which is used in the treatment of high-risk NB patients with recurrent/residual disease in the bone marrow, is able to upregulate Wnt -5a gene expression.
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Analysis of Dickkopf3 interactions with Wnt signaling receptors
TL;DR: It is reported that, contrary to previous studies, Dkk3 interacts with Krm1 and Krm2, but did not interact with, or alter expression of, LRP6.
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Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro
TL;DR: It is shown that Aβ1–42-induced loss of synaptophysin from neuronal cultures was also reduced by pre-treatment with other PAF antagonists (Hexa-PAF and CV6209), suggesting that the ginkgolides are active components of Ginkgo biloba preparations and may protect against the synapse damage and the cognitive loss seen during the early stages of AD.
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Wnt5b–Ryk pathway provides directional signals to regulate gastrulation movement
TL;DR: The soluble ligand Wnt5b repels cells expressing the Ryk (related to tyrosine kinase) receptor, establishing directional motility during gastrulation.
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Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2
TL;DR: It is shown that Ror2 is phosphorylated on serine/threonine residues upon stimulation of cultured cells, expressing Ror 2 endogenously, with Wnt5a, but not Wnt3a, which indicates that GSK‐3 is involved in Wnt 5a‐induced phosphorylation of ROr2.