Journal ArticleDOI
Wnt/Ca2+ signaling pathway: a brief overview
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TLDR
This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.Abstract:
The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca(2+) signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca(2+) pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.read more
Citations
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Journal ArticleDOI
Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
Kinjal Shah,Julhash U. Kazi +1 more
TL;DR: An overview of how protein phosphorylation controls WNT/β-catenin signaling, particularly in human cancer, is provided.
Book ChapterDOI
Extracellular Regulation of the Mitotic Spindle and Fate Determinants Driving Asymmetric Cell Division.
TL;DR: The capacity to influence stem cells makes these secreted factors excellent targets for therapeutic strategies designed to enhance cell populations in degenerative disease or restrict cell proliferation in different types of cancers.
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Wnt signalling pathway in bladder cancer.
Guanlin Wu,Guanlin Wu,Weidong Weng,Pengfei Xia,Pengfei Xia,Shixian Yan,Shixian Yan,Cheng Zhong,Cheng Zhong,Lei Xie,Yu Xie,Gang Fan,Gang Fan,Gang Fan +13 more
TL;DR: This review aims to summarise previous studies related to BC and the Wnt signalling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the WNT signalling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets and diagnostic biomarkers.
Journal ArticleDOI
The Wnt Signaling Pathway in Diabetic Nephropathy
Haiying Wang,Ran Zhang,Xinjie Wu,Yafen Chen,Wei Ji,Jingsuo Wang,Yawen Zhang,Yong Xia,Yi‐qun Tang,Jinxian Yuan +9 more
TL;DR: Evidence is uncovered supporting that both Wnt/PCP andWnt/Ca2+ signaling are critical for DN development, and the significance of the Wnt canonical pathway in the process of DN is elucidated.
Journal ArticleDOI
Aberrant Wnt Signaling Pathway in the Hematopoietic Stem/Progenitor Compartment in Experimental Leukemic Animal
TL;DR: Assessment of the expression profile of Wnt proteins, receptors, key signaling intermediates and endogenous Wnt antagonist involved in canonical and non-canonical pathways in the bone marrow hematopoietic stem/progenitor cell (HSPC) compartment of experimental leukemic mice resulted in progression of leukemia.
References
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Peter A. Jones,Stephen B. Baylin +1 more
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Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
Journal ArticleDOI
Wnt proteins are lipid-modified and can act as stem cell growth factors
Karl Willert,Jeffrey Brown,Esther Danenberg,Andrew W. Duncan,Irving L. Weissman,Tannishtha Reya,John R. Yates,Roel Nusse +7 more
TL;DR: This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
Journal ArticleDOI
Transcriptional regulation by calcium, calcineurin, and NFAT
TL;DR: The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response.