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Journal ArticleDOI
A review of saliva: Normal composition, flow, and function
TL;DR: A brief, up-to-date overview of the literature on the basics of normal salivary composition, flow, and function is provided.
Journal ArticleDOI
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.
TL;DR: It is proposed that XBP‐1 is both necessary and sufficient for the full biogenesis of the secretory machinery in exocrine cells.
Journal ArticleDOI
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions
Paul C. Denny,Fred K. Hagen,Markus Hardt,Lujian Liao,Weihong Yan,Martha Arellanno,Sara Bassilian,Gurrinder S. Bedi,Pinmannee Boontheung,Daniel Cociorva,Claire M. Delahunty,Trish Denny,Jason Dunsmore,Kym F. Faull,Joyce Gilligan,Mireya Gonzalez-Begne,Frédéric Halgand,Steven C. Hall,Xuemei Han,Bradley S. Henson,Johannes Hewel,Shen Hu,Sherry Jeffrey,Jiang Jiang,Joseph A. Loo,Rachel R. Ogorzalek Loo,Daniel Malamud,James E. Melvin,Olga Miroshnychenko,Mahvash Navazesh,Richard K. Niles,Sung Kyu Park,Akraporn Prakobphol,Prasanna Ramachandran,Megan Richert,Sarah Robinson,Melissa Sondej,Puneet Souda,Mark A. Sullivan,Jona Takashima,Shawn Than,Jianghua Wang,Julian P. Whitelegge,H. Ewa Witkowska,Lawrence E. Wolinsky,Yongming Xie,Tao Xu,Weixia Yu,Jimmy Ytterberg,David T.W. Wong,John R. Yates,Susan J. Fisher +51 more
TL;DR: A catalogue of the salivary proteome of healthy individuals allows future analyses ofSaliva samples from individuals with oral and systemic diseases, with the goal of identifying biomarkers with diagnostic and/or prognostic value for these conditions; another possibility is the discovery of therapeutic targets.
Journal ArticleDOI
Saliva: a Dynamic Proteome
TL;DR: Understanding the proteome of whole saliva in an environment of continuous turnover will be a prerequisite to gain insight into the physiological and pathological processes relevant to oral health, and be crucial for the identification of meaningful biomarkers for oral disease.
Journal ArticleDOI
Sequential interactions with Sec23 control the direction of vesicle traffic
Christopher L. Lord,Deepali Bhandari,Shekar Menon,Majid Ghassemian,Deborah C. Nycz,Jesse C. Hay,Pradipta Ghosh,Susan Ferro-Novick +7 more
TL;DR: It is demonstrated that an ER-derived vesicle retains its coat until it reaches the Golgi and that Sec23p interacts in a sequential manner with different binding partners, including TRAPPI and Hrr25p, to ensure the directionality of ER–Golgi traffic and prevent the back-fusion of a COPII vesicles with the ER.