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Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials

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TLDR
In this paper, the authors conducted a collaborative meta-analysis to clarify the risks and benefits of adjuvant bisphosphonate treatment in early breast cancer, and found that the reduction in bone recurrence was more definite (0.73-0.94; 2p=0.004).
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This article is published in The Lancet.The article was published on 2015-10-03 and is currently open access. It has received 554 citations till now. The article focuses on the topics: Breast cancer & Zoledronic acid.

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Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

TL;DR: This work presents the results of a meta-analysis conducted at the 2016 European Oncology and Radiotherapy Guidelines Working Group (ESMO) workshop on breast cancer diagnosis and prognosis of women with atypical central giant cell granuloma (CGM) who have previously had surgery.
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Metastatic colonization by circulating tumour cells

TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
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De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017

Giuseppe Curigliano, +53 more
- 01 Aug 2017 - 
TL;DR: The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer, and recommended bisphosphonate use in postmenopausal women to prevent breast cancer recurrence.
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Featured Updates to the NCCN Guidelines

TL;DR: The major changes to the 2012 and 2011 NCCN Guidelines for Soft Tissue Sarcoma pertain to the management of patients with gastrointestinal stromal tumors and desmoid tumors.
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Estimating the Benefits of Therapy for Early Stage Breast Cancer The St Gallen International Consensus Guidelines for the Primary Therapy of Early Breast Cancer 2019

TL;DR: The 16th St. Gallen International Breast Cancer Conference 2019 as mentioned in this paper reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer, and encouraged clinicians and patients to routinely discuss the magnitude of benefit for interventions as part of the development of the treatment plan.
References
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Journal ArticleDOI

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

O. Abe, +412 more
- 14 May 2005 - 
TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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Metastasis to bone: causes, consequences and therapeutic opportunities

TL;DR: The most common human cancers — lung, breast and prostate — have a great avidity for bone, leading to painful and untreatable consequences.
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Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

TL;DR: The absolute risk reductions produced by tamoxifen depend on the absolute breast cancer risks (after any chemotherapy) without tamox ifen, so all-cause mortality was substantially reduced.
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Mechanisms of bone metastasis.

TL;DR: Bone metastasis causes severe bone pain and can result in fractures without any injury, as well as other life-threatening conditions, and patients with prostate cancer who usually have bone metastasis that shows increased new bone formation also have increased bone destruction in the same lesions.
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Cancer to bone: a fatal attraction

TL;DR: Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases.
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