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Showing papers on "Network theory published in 2014"


Journal ArticleDOI
TL;DR: This work offers a comprehensive review on both structural and dynamical organization of graphs made of diverse relationships (layers) between its constituents, and cover several relevant issues, from a full redefinition of the basic structural measures, to understanding how the multilayer nature of the network affects processes and dynamics.

2,669 citations


Journal ArticleDOI
TL;DR: It is found that both search information and path transitivity predict the strength of functional connectivity among both connected and unconnected node pairs at levels that match or significantly exceed path length measures, Euclidean distance, as well as computational models of neural dynamics.
Abstract: The complex relationship between structural and functional connectivity, as measured by noninvasive imaging of the human brain, poses many unresolved challenges and open questions. Here, we apply analytic measures of network communication to the structural connectivity of the human brain and explore the capacity of these measures to predict resting-state functional connectivity across three independently acquired datasets. We focus on the layout of shortest paths across the network and on two communication measures—search information and path transitivity—which account for how these paths are embedded in the rest of the network. Search information is an existing measure of information needed to access or trace shortest paths; we introduce path transitivity to measure the density of local detours along the shortest path. We find that both search information and path transitivity predict the strength of functional connectivity among both connected and unconnected node pairs. They do so at levels that match or significantly exceed path length measures, Euclidean distance, as well as computational models of neural dynamics. This capacity suggests that dynamic couplings due to interactions among neural elements in brain networks are substantially influenced by the broader network context adjacent to the shortest communication pathways.

561 citations


Journal ArticleDOI
TL;DR: This study tries to provide a mathematically sound survey of the most important classic centrality measures known from the literature and proposes an axiomatic approach to establish whether they are actually doing what they have been designed to do, and suggests that centrality Measures based on distances, which in recent years have been neglected in information retrieval, do provide high-quality signals.
Abstract: Given a social network, which of its nodes are more central? This question has been asked many times in sociology, psychology, and computer science, and a whole plethora of centrality measures (a.k.a. centrality indices, or rankings) were proposed to account for the importance of the nodes of a network. In this study, we try to provide a mathematically sound survey of the most important classic centrality measures known from the literature and propose an axiomatic approach to establish whether they are actually doing what they have been designed to do. Our axioms suggest some simple, basic properties that a centrality measure should exhibit.Surprisingly, only a new simple measure based on distances, harmonic centrality, turns out to satisfy all axioms; essentially, harmonic centrality is a correction to Bavelas’s classic closeness centrality [Bavelas 50] designed to take unreachable nodes into account in a natural way.As a sanity check, we examine in turn each measure under the lens of information...

407 citations


Journal ArticleDOI
TL;DR: In this article, a comprehensive review on both structural and dynamical organization of graphs made of diverse relationships (layers) between its constituents, and cover several relevant issues, from a full redefinition of the basic structural measures, to understanding how the multilayer nature of the network affects processes and dynamics.
Abstract: In the past years, network theory has successfully characterized the interaction among the constituents of a variety of complex systems, ranging from biological to technological, and social systems. However, up until recently, attention was almost exclusively given to networks in which all components were treated on equivalent footing, while neglecting all the extra information about the temporal- or context-related properties of the interactions under study. Only in the last years, taking advantage of the enhanced resolution in real data sets, network scientists have directed their interest to the multiplex character of real-world systems, and explicitly considered the time-varying and multilayer nature of networks. We offer here a comprehensive review on both structural and dynamical organization of graphs made of diverse relationships (layers) between its constituents, and cover several relevant issues, from a full redefinition of the basic structural measures, to understanding how the multilayer nature of the network affects processes and dynamics.

401 citations


Book ChapterDOI
14 Jul 2014
TL;DR: In this article, the authors discuss the fundamental characteristics of network theory and provide their thoughts on opportunities for future research in social network analysis, and address some previous critiques and controversies surrounding the issues of structure, human agency, endogeneity, tie content, network change and context.
Abstract: Is social network analysis just measures and methods with no theory? We attempt to clarify some confusions, address some previous critiques and controversies surrounding the issues of structure, human agency, endogeneity, tie content, network change, and context, and add a few critiques of our own. We use these issues as an opportunity to discuss the fundamental characteristics of network theory and to provide our thoughts on opportunities for future research in social network analysis.

180 citations


Journal ArticleDOI
TL;DR: A local structural centrality measure is proposed which considers both the number and the topological connections of the neighbors of a node, and can rank the spreading ability of nodes more accurately than centrality measures such as degree, k-shell, betweenness, closeness and local centrality.
Abstract: Ranking nodes by their spreading ability in complex networks is a fundamental problem which relates to wide applications. Local metric like degree centrality is simple but less effective. Global metrics such as betweenness and closeness centrality perform well in ranking nodes, but are of high computational complexity. Recently, to rank nodes effectively and efficiently, a semi-local centrality measure has been proposed as a tradeoff between local and global metrics. However, in semi-local centrality, only the number of the nearest and the next nearest neighbors of a node is taken into account, while the topological connections among the neighbors are neglected. In this paper, we propose a local structural centrality measure which considers both the number and the topological connections of the neighbors of a node. To evaluate the performance of our method, we use the Susceptible–Infected–Recovered (SIR) model to simulate the epidemic spreading process on both artificial and real networks. By measuring the rank correlation between the ranked list generated by simulation results and the ones generated by centrality measures, we show that our method can rank the spreading ability of nodes more accurately than centrality measures such as degree, k -shell, betweenness, closeness and local centrality. Further, we show that our method can better distinguish the spreading ability of nodes.

146 citations


Proceedings ArticleDOI
23 Jun 2014
TL;DR: The betweenness centrality measure is re-define to account for the inherent structure of multiplex networks and an algorithm to compute it in an efficient way is proposed and shown to be more accurate than the current approach.
Abstract: The vertiginous increase of e-platforms for social communication has boosted the ways people use to interact each other. Micro-blogging and decentralized posts are used indistinctly for social interaction, usually by the same individuals acting simultaneously in the different platforms. Multiplex networks are the natural abstraction representation of such "layered" relationships and others, like co-authorship. Here, we re-define the betweenness centrality measure to account for the inherent structure of multiplex networks and propose an algorithm to compute it in an efficient way. To show the necessity and the advantage of the proposed definition, we analyze the obtained centralities for two real multiplex networks, a social multiplex of two layers obtained from Twitter and Instagram and a co-authorship network of four layers obtained from arXiv. Results show that the proposed definition provides more accurate results than the current approach of evaluating the classical betweenness centrality on the aggregated network, in particular for the middle ranked nodes. We also analyze the computational cost of the presented algorithm.

129 citations


Journal ArticleDOI
TL;DR: It is shown that the density of nodes with in degree and out degree equal to one and two determines the number of driver nodes in the network, and an algorithm is proposed to improve the controllability of networks.
Abstract: The problem of controllability of the dynamical state of a network is central in network theory and has wide applications ranging from network medicine to financial markets. The driver nodes of the network are the nodes that can bring the network to the desired dynamical state if an external signal is applied to them. Using the framework of structural controllability, here, we show that the density of nodes with in degree and out degree equal to one and two determines the number of driver nodes in the network. Moreover, we show that random networks with minimum in degree and out degree greater than two, are always fully controllable by an infinitesimal fraction of driver nodes, regardless of the other properties of the degree distribution. Finally, based on these results, we propose an algorithm to improve the controllability of networks.

128 citations


Journal ArticleDOI
TL;DR: The new notion of maximal equilibrium independent passivity is introduced and it is shown that networks of systems possessing this property asymptotically approach the solutions of a dual pair of network optimization problems, namely an optimal potential and an optimal flow problem.

123 citations


Journal ArticleDOI
TL;DR: This article reviews different kinds of models for the electric power grid that can be used to understand the modern power system, the smart grid, and indicates possible ways to incorporate the diverse co-evolving systems into the smartgrid model using, for example, network theory and multi-agent simulation.
Abstract: This article reviews different kinds of models for the electric power grid that can be used to understand the modern power system, the smart grid. From the physical network to abstract energy markets, we identify in the literature different aspects that co-determine the spatio-temporal multilayer dynamics of power system. We start our review by showing how the generation, transmission and distribution characteristics of the traditional power grids are already subject to complex behaviour appearing as a result of the the interplay between dynamics of the nodes and topology, namely synchronisation and cascade effects. When dealing with smart grids, the system complexity increases even more: on top of the physical network of power lines and controllable sources of electricity, the modernisation brings information networks, renewable intermittent generation, market liberalisation, prosumers, among other aspects. In this case, we forecast a dynamical co-evolution of the smart grid and other kind of networked systems that cannot be understood isolated. This review compiles recent results that model electric power grids as complex systems, going beyond pure technological aspects. From this perspective, we then indicate possible ways to incorporate the diverse co-evolving systems into the smart grid model using, for example, network theory and multi-agent simulation.

122 citations


Journal ArticleDOI
TL;DR: A way to incorporate nonlinear dynamics and dependencies into hierarchical networks to study financial markets using mutual information and its dynamical extension: the mutual information rate is introduced.
Abstract: In the last few years there have been many efforts in econophysics studying how network theory can facilitate understanding of complex financial markets. These efforts consist mainly of the study of correlation-based hierarchical networks. This is somewhat surprising as the underlying assumptions of research looking at financial markets are that they are complex systems and thus behave in a nonlinear manner, which is confirmed by numerous studies, making the use of correlations which are inherently dealing with linear dependencies only baffling. In this paper we introduce a way to incorporate nonlinear dynamics and dependencies into hierarchical networks to study financial markets using mutual information and its dynamical extension: the mutual information rate. We show that this approach leads to different results than the correlation-based approach used in most studies, on the basis of 91 companies listed on the New York Stock Exchange 100 between 2003 and 2013, using minimal spanning trees and planar maximally filtered graphs.

Journal ArticleDOI
07 Apr 2014-PLOS ONE
TL;DR: It is discovered that as compared with other centrality measures, Eigenvector and Eccentricity Centralities were better able to identify important nodes.
Abstract: Background Living systems are associated with Social networks — networks made up of nodes, some of which may be more important in various aspects as compared to others. While different quantitative measures labeled as “centralities” have previously been used in the network analysis community to find out influential nodes in a network, it is debatable how valid the centrality measures actually are. In other words, the research question that remains unanswered is: how exactly do these measures perform in the real world? So, as an example, if a centrality of a particular node identifies it to be important, is the node actually important?

Journal ArticleDOI
09 Jun 2014-PLOS ONE
TL;DR: A way to understand whether an article bridges among extant strands of literature and infer the size of its research community and its embeddedness is proposed by creating a network on the basis of shared references.
Abstract: This paper analyzes the effects of the co-authorship and bibliographic coupling networks on the citations received by scientific articles. It expands prior research that limited its focus on the position of co-authors and incorporates the effects of the use of knowledge sources within articles: references. By creating a network on the basis of shared references, we propose a way to understand whether an article bridges among extant strands of literature and infer the size of its research community and its embeddedness. Thus, we map onto the article – our unit of analysis – the metrics of authors' position in the co-authorship network and of the use of knowledge on which the scientific article is grounded. Specifically, we adopt centrality measures – degree, betweenneess, and closeness centrality – in the co-authorship network and degree, betweenness centrality and clustering coefficient in the bibliographic coupling and show their influence on the citations received in first two years after the year of publication. Findings show that authors' degree positively impacts citations. Also closeness centrality has a positive effect manifested only when the giant component is relevant. Author's betweenness centrality has instead a negative effect that persists until the giant component - largest component of the network in which all nodes can be linked by a path - is relevant. Moreover, articles that draw on fragmented strands of literature tend to be cited more, whereas the size of the scientific research community and the embeddedness of the article in a cohesive cluster of literature have no effect.

Journal ArticleDOI
04 Feb 2014-PeerJ
TL;DR: It is shown that properties of the degree distribution are driven by network connectance, which has implications for the generation of random networks in null-model analyses and the interpretation of network structure and ecosystem properties in relationship with degree distribution.
Abstract: Connectance and degree distributions are important components of the structure of ecological networks. In this contribution, we use a statistical argument and simple network generating models to show that properties of the degree distribution are driven by network connectance. We discuss the consequences of this finding for (1) the generation of random networks in null-model analyses, and (2) the interpretation of network structure and ecosystem properties in relationship with degree distribution.

Journal ArticleDOI
TL;DR: This work investigates the cost-effective massive viral marketing problem, taking into the consideration the limited influence propagation, and provides mathematical programming to find optimal seeding for medium-size networks and proposes VirAds, an efficient algorithm, to tackle the problem on large-scale networks.
Abstract: Online social networks (OSNs) have become one of the most effective channels for marketing and advertising. Since users are often influenced by their friends, “word-of-mouth” exchanges, so-called viral marketing, in social networks can be used to increase product adoption or widely spread content over the network. The common perception of viral marketing about being cheap, easy, and massively effective makes it an ideal replacement of traditional advertising. However, recent studies have revealed that the propagation often fades quickly within only few hops from the sources, counteracting the assumption on the self-perpetuating of influence considered in literature. With only limited influence propagation, is massively reaching customers via viral marketing still affordable? How do we economically spend more resources to increase the spreading speed? We investigate the cost-effective massive viral marketing problem, taking into the consideration the limited influence propagation. Both analytical analysis based on power-law network theory and numerical analysis demonstrate that the viral marketing might involve costly seeding. To minimize the seeding cost, we provide mathematical programming to find optimal seeding for medium-size networks and propose VirAds, an efficient algorithm, to tackle the problem on large-scale networks. VirAds guarantees a relative error bound of $O(1)$ from the optimal solutions in power-law networks and outperforms the greedy heuristics that realizes on the degree centrality. Moreover, we also show that, in general, approximating the optimal seeding within a ratio better than $O(\log n)$ is unlikely possible.

Journal ArticleDOI
28 Jun 2014
TL;DR: In this paper, the authors discuss how complexity is viewed in governance network theory and provide a systematic elaboration of the notion of complexity, distinguishing three types: substantive, strategic, and institutional complexity.
Abstract: In this article, we discuss how complexity is viewed in governance network theory. The article provides a systematic elaboration of the notion of complexity, distinguishing three types: substantive, strategic , and institutional complexity. We argue that dealing with these types of complexity in networks is essentially a matter of mutual adaption and cooperation. An important explanation for the occurrence of deadlocks, breakthroughs and outcomes is the presence and the quality of attempts to manage complex interaction processes in networks.

Proceedings ArticleDOI
01 Oct 2014
TL;DR: In this paper, the authors proposed a scalable algorithm for computing the classic closeness centrality of all nodes in the graph, within a small relative error, for both directed and undirected graphs.
Abstract: Closeness centrality, first considered by Bavelas (1948), is an importance measure of a node in a network which is based on the distances from the node to all other nodes. The classic definition, proposed by Bavelas (1950), Beauchamp (1965), and Sabidussi (1966), is (the inverse of) the average distance to all other nodes.We propose the first highly scalable (near linear-time processing and linear space overhead) algorithm for estimating, within a small relative error, the classic closeness centralities of all nodes in the graph. Our algorithm applies to undirected graphs, as well as for centrality computed with respect to round-trip distances in directed graphs.For directed graphs, we also propose an efficient algorithm that approximates generalizations of classic closeness centrality to outbound and inbound centralities. Although it does not provide worst-case theoretical approximation guarantees, it is designed to perform well on real networks.We perform extensive experiments on large networks, demonstrating high scalability and accuracy.

Journal ArticleDOI
TL;DR: In this article, the performance of several network centrality measures in detecting systemically important financial institutions (SIFI) using data from the Turkish Interbank market during the financial crisis in 2000 was analyzed.
Abstract: In this paper, we analyze the performance of several network centrality measures in detecting systemically important financial institutions (SIFI) using data from the Turkish Interbank market during the financial crisis in 2000. We employ various network investigation tools such as volume, transactions, links, connectivity and reciprocity to gain a clearer picture of the network topology of the interbank market. We study the main borrower role of Demirbank in the crash of the banking system with network centrality measures which are extensively used in the network theory. This ex-post analysis of the crisis shows that centrality measures perform well in identifying and monitoring systemically important financial institutions which provide useful insights for financial regulations.

Journal ArticleDOI
TL;DR: In this paper, experiential knowledge antecedents of the network node configuration (i.e., dyad or triad) of SMEs entering emerging market business networks are determined.

Journal ArticleDOI
TL;DR: A method of determining protein structure networks by calculating inter-residue interaction energies is proposed and it is shown that it gives an accurate and reliable description of the signal-propagation properties of a known allosteric enzyme.
Abstract: Network theory methods are being increasingly applied to proteins to investigate complex biological phenomena. Residues that are important for signaling processes can be identified by their condition as critical nodes in a protein structure network. This analysis involves modeling the protein as a graph in which each residue is represented as a node and edges are drawn between nodes that are deemed connected. In this paper, we show that the results obtained from this type of network analysis (i.e., signaling pathways, key residues for signal transmission, etc.) are profoundly affected by the topology of the network, with normally used determination of network edges by geometrical cutoff schemes giving rise to substantial statistical errors. We propose a method of determining protein structure networks by calculating inter-residue interaction energies and show that it gives an accurate and reliable description of the signal-propagation properties of a known allosteric enzyme. We also show that including co...

Book ChapterDOI
01 Jan 2014
TL;DR: The analytical framework and the results for percolation laws for a network of networks (NON) formed by \(n\) interdependent random networks are reviewed and some possible real-world applications of NON theory are reviewed.
Abstract: Complex networks appear in almost every aspect of science and technology. Previous work in network theory has focused primarily on analyzing single networks that do not interact with other networks, despite the fact that many real-world networks interact with and depend on each other. Very recently an analytical framework for studying the percolation properties of interacting networks has been introduced. Here we review the analytical framework and the results for percolation laws for a network of networks (NON) formed by \(n\) interdependent random networks. The percolation properties of a network of networks differ greatly from those of single isolated networks. In particular, although networks with broad degree distributions, e.g., scale-free networks, are robust when analyzed as single networks, they become vulnerable in a NON. Moreover, because the constituent networks of a NON are connected by node dependencies, a NON is subject to cascading failure. When there is strong interdependent coupling between networks, the percolation transition is discontinuous (is a first-order transition), unlike the well-known continuous second-order transition in single isolated networks. We also review some possible real-world applications of NON theory.

Journal ArticleDOI
TL;DR: This paper analyzes the growth and evolution of topological features of the US airline network over a 20-year period, and explores the correlation between different measures, and investigates various interactions inside the network.
Abstract: This paper analyzes the growth and evolution of topological features of the US airline network over a 20-year period. It captures the change in the network system from different dimensions of complex networks such as centrality distribution and various structural properties of the network over time. We first illustrate the results of a set of measures, including degree, strength, betweenness centrality, and clustering structure. The geographic features of airport systems, spatial distance and network efficiency are also discussed in this section. In order to further capture the dynamics of the system, this paper also explores the correlation between different measures, and investigates various interactions inside the network. Overall this study offers a novel approach to understanding the growth and evolution of real physical networks.

Proceedings ArticleDOI
24 Aug 2014
TL;DR: This paper presents a method that directly solves the task of choosing the k vertices with the maximum adaptive betweenness centrality without considering the shortest paths that have been taken into account by already-chosen vertices, and theoretically and experimentally proves that this method is very accurate and three orders of magnitude faster than previous methods.
Abstract: Betweenness centrality measures the importance of a vertex by quantifying the number of times it acts as a midpoint of the shortest paths between other vertices. This measure is widely used in network analysis. In many applications, we wish to choose the k vertices with the maximum adaptive betweenness centrality, which is the betweenness centrality without considering the shortest paths that have been taken into account by already-chosen vertices. All previous methods are designed to compute the betweenness centrality in a fixed graph. Thus, to solve the above task, we have to run these methods $k$ times. In this paper, we present a method that directly solves the task, with an almost linear runtime no matter how large the value of k. Our method first constructs a hypergraph that encodes the betweenness centrality, and then computes the adaptive betweenness centrality by examining this graph. Our technique can be utilized to handle other centrality measures. We theoretically prove that our method is very accurate, and experimentally confirm that it is three orders of magnitude faster than previous methods. Relying on the scalability of our method, we experimentally demonstrate that strategies based on adaptive betweenness centrality are effective in important applications studied in the network science and database communities.


Journal ArticleDOI
TL;DR: The effect of topology on residue interaction network was investigated for two different proteins: Dronpa and a DNA clamp, which have cylindrical and toroidal topologies, respectively.

Journal ArticleDOI
TL;DR: A new measure of node centrality in social networks, the Harmonic Influence Centrality (HIC), which emerges naturally in the study of social influence over networks is proposed using an intuitive analogy between social and electrical networks.
Abstract: This paper proposes a new measure of node centrality in social networks, the Harmonic Influence Centrality (HIC), which emerges naturally in the study of social influence over networks. Using an intuitive analogy between social and electrical networks, we introduce a distributed message passing algorithm to compute the HIC of each node. Although its design is based on theoretical results which assume the network to have no cycle, the algorithm can also be successfully applied on general graphs.

Posted Content
TL;DR: In this paper, the authors show how topology and weights can play distinct roles in rich-clubs and discuss how several previous reports of weighted rich clubs conflated the two using inappropriate controls.
Abstract: Network theory helps uncover organizational features of complex systems. In many real-world networks, exclusive groups of highly linked elements form rich clubs, which have key functional roles. Detecting rich clubs when links are weighted is non-trivial however, and multiple metrics have been proposed. We reduce these metrics to a single form by integrating the role of randomized controls. Using this framework we show how topology and weights can play distinct roles in rich-clubs and discuss how several previous reports of weighted rich clubs conflated the two using inappropriate controls.

Journal ArticleDOI
TL;DR: In this paper, the authors developed a network theory-based framework of manufacturing joint venture formations and provided an empirical test in the context of the automotive industry using a comprehensive time series panel dataset containing the joint venture information of 1,158 automotive firms collectively engaging in 589 manufacturing joint ventures over 19 years.
Abstract: This article develops a network theory�based framework of manufacturing joint venture formations and provides an empirical test in the context of the automotive industry. Hypotheses are developed regarding the implications of the network structure for a firm's partner selection in manufacturing joint ventures. The roles of network theory constructs such as ego network size, ego network density, and ego network betweenness centrality on new manufacturing joint venture formations are explored using a dynamic framework. A comprehensive time series panel dataset with 3,247,124 observations containing the joint venture information of 1,158 automotive firms collectively engaging in 589 manufacturing joint ventures over 19 years is utilized to test the hypotheses. Results provide strong empirical support for the role of network structure in equity-based partnership formation. Specifically, ego network size and ego network betweenness centrality of both the focal manufacturer and potential partner have significant effects on new manufacturing joint venture formations. Findings regarding the role of ego network density are mixed

Proceedings ArticleDOI
01 Oct 2014
TL;DR: This research applied degree and eigenvector centrality to observe the effect of centrality value for twitter data and shows that there is significant difference among 10 most influential users.
Abstract: Network formed between users in a social media can be used to encourage information spreading among them. This research applied Social Network Analysis which further can be used to social media marketing to improve the marketing process effectively. Based on previous research, information spreading speed among the social media is affected by the users' activity connection which can be represented in centrality value. The centrality value itself is very affected by the graph structure and weights. This research applied degree and eigenvector centrality to observe the effect of centrality value for twitter data. The result shows that there is significant difference among 10 most influential users. This result will be used for the future research that will be focused in small and medium enterprise (SME) twitter data.

MonographDOI
01 Jan 2014
TL;DR: This chapter discusses Governance Network Theory as a Composite Theory of Leadership and Management: Process Catalyst and Strategic Leveraging-Theory of Deliberate Action in Collaborative Networks, and two Perspectives on Complexity Theory.
Abstract: Part 1. Introduction to the Issues/Current Network Theories 1. Introduction: Understanding Theory Myrna P. Mandell 2. Network Theory Tracks and Trajectories: Where From, Where To? Robyn Keast Part 2. New Theoretical Frameworks: Informing Design, Governance Arrangements and Management 3. A Composite Theory of Leadership and Management: Process Catalyst and Strategic Leveraging-Theory of Deliberate Action in Collaborative Networks Robyn Keast and Myrna P. Mandell 4. Building and Using the Theory of Collaborative Advantage Siv Vangen and Chris Huxham 5. The Democratic Potentials of Governance Networks in Inter- Governmental Decision Making Eva Sorensen 6. Governance Network Performance: A Complex Adaptive Systems Approach Christopher Koliba 7. Governing Through Networks: A Systemic Approach Deborah Rice 8. Network Management Theory through Management Channels and Roles Joris Voets Part 3. Putting Theory into Practice 9. Network Management Behaviors: Closing the Theoretical Gap Robert Agranoff and Michael McGuire 10. What Can Governance Network Theory Learn From Complexity Theory? Mirroring Two Perspectives on Complexity Joop Koppenjan and Erik-Hans Klijn 11. Network Performance: Towards A Dynamic Multidimensional Model Denita Cepiku Part 4. Implications and Conclusion 12. Bridging the Theoretical Gap and Uncovering the Missing Holes Robert Agranoff