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Adam H. Hart
Researcher at La Trobe University
Publications - 28
Citations - 3130
Adam H. Hart is an academic researcher from La Trobe University. The author has contributed to research in topics: Cellular differentiation & Trophy. The author has an hindex of 14, co-authored 20 publications receiving 2895 citations. Previous affiliations of Adam H. Hart include Walter and Eliza Hall Institute of Medical Research & Monash University.
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Journal ArticleDOI
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim,Elgene Lim,François Vaillant,Di Wu,Di Wu,Natasha C. Forrest,Bhupinder Pal,Adam H. Hart,Marie Liesse Asselin-Labat,David E. Gyorki,David E. Gyorki,Teresa Ward,Audrey Partanen,Frank Feleppa,Lily I. Huschtscha,Heather Thorne,Stephen B. Fox,Max Yan,Juliet D. French,Melissa A. Brown,Gordon K. Smyth,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +24 more
TL;DR: It is found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro, and the findings suggest that an aberrant luminalprogenitor population is a target for transformation in BRCa1-associated basal tumors.
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Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia
Adam H. Hart,Fabrice Melet,Paul Grossfeld,Kenneth R. Chien,Christopher Jones,Alan Tunnacliffe,Rémi Favier,Alan Bernstein,Alan Bernstein,Alan Bernstein +9 more
TL;DR: It is suggested that dysmegakaryopoiesis in Jacobsen patients may be caused by hemizygous loss of Fli-1, the ETS gene involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children.
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Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human.
TL;DR: The conservation in gene sequence, structure, and expression of mouse and human Nanog and Nanog2 genes may reflect a common role in the maintenance of pluripotency in both species.
Journal ArticleDOI
Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape
Eugenio Marco,Robert L. Karp,Guoji Guo,Paul Robson,Adam H. Hart,Lorenzo Trippa,Guo-Cheng Yuan +6 more
TL;DR: SCUBA provides a useful single-cell data analysis tool that is well-suited for the investigation of developmental processes and analysis of a hematopoietic dataset suggests that the method is effective for reconstructing gene expression dynamics during human B-cell development.
Journal ArticleDOI
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
Adam H. Hart,Lynne Hartley,Koula Sourris,Elizabeth Siewsun Stadler,Ruili Li,Edouard G. Stanley,Patrick P.L. Tam,Andrew G. Elefanty,Lorraine Robb +8 more
TL;DR: In chimeras, Mixl1(-/-) mutant cells can contribute to all embryonic structures, with the exception of the hindgut, suggesting that Mixl 1 activity is most crucial for endodermal differentiation.