A
Akio Mimori
Researcher at Saitama Medical University
Publications - 107
Citations - 2842
Akio Mimori is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Lupus erythematosus & Rheumatoid arthritis. The author has an hindex of 29, co-authored 107 publications receiving 2533 citations.
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Journal ArticleDOI
A functional variant in FCRL3 , encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Yuta Kochi,Ryo Yamada,Akari Suzuki,John B. Harley,John B. Harley,John B. Harley,Senji Shirasawa,Tetsuji Sawada,Sang Cheol Bae,Shinya Tokuhiro,Xiaotian Chang,Akihiro Sekine,Atsushi Takahashi,Tatsuhiko Tsunoda,Yozo Ohnishi,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,Changsoo Paul Kang,Changwon Kang,Shigeru Otsubo,Wako Yumura,Akio Mimori,Takao Koike,Yusuke Nakamura,Takehiko Sasazuki,Kazuhiko Yamamoto +26 more
TL;DR: A SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis is identified and this polymorphism alters the binding affinity of nuclear factor-κB and regulatesFCRL3 expression.
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A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese
Yukinori Okada,Kenichi Shimane,Yuta Kochi,Tomoko Tahira,Akari Suzuki,Koichiro Higasa,Atsushi Takahashi,Tetsuya Horita,Tatsuya Atsumi,Tomonori Ishii,Akiko Okamoto,Keishi Fujio,Michito Hirakata,Hirofumi Amano,Yuya Kondo,Satoshi Ito,Kazuki Takada,Akio Mimori,Kazuyoshi Saito,Makoto Kamachi,Yasushi Kawaguchi,Katsunori Ikari,Osman Wael Mohammed,Koichi Matsuda,Chikashi Terao,Koichiro Ohmura,Keiko Myouzen,Naoya Hosono,Tatsuhiko Tsunoda,Norihiro Nishimoto,Tsuneyo Mimori,Fumihiko Matsuda,Yoshiya Tanaka,Takayuki Sumida,Hisashi Yamanaka,Yoshinari Takasaki,Takao Koike,Takahiko Horiuchi,Kenshi Hayashi,Michiaki Kubo,Naoyuki Kamatani,Ryo Yamada,Yusuke Nakamura,Kazuhiko Yamamoto +43 more
TL;DR: A genome-wide association study for SLE examining 891 Sle cases and 3,384 controls and multi-stage replication studies examining 1,387 SLE cases and 28,564 controls in Japanese subjects integrated an eQTL study into the results of the GWAS, identifying a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with SLE susceptibility.
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Whole-body FDG-PET/CT on rheumatoid arthritis of large joints
Kazuo Kubota,Kimiteru Ito,Miyako Morooka,Takuya Mitsumoto,Kyoko Kurihara,Hiroyuki Yamashita,Yuko Takahashi,Akio Mimori +7 more
TL;DR: FDG-PET/CT represents the inflammatory activity in large joints in patients with RA accurately and sensitively and may be helpful for early evaluations of the extent of RA throughout the whole body including high risk lesion of atlanto-axial joint.
Journal ArticleDOI
Benefit and a possible risk of tocilizumab therapy for adult-onset Still’s disease accompanied by macrophage-activation syndrome
TL;DR: Tocilizumab may be useful for maintenance therapy for AOSD, although its efficacy is unclear for the highly active phase of the disease.
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Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases.
TL;DR: Autoantibodies to ACE2 may be associated with constrictive vasculopathies, and immunosuppressive therapy given to one SLE patient with digital necrosis markedly decreased the anti-ACE2 antibody titer and restored serum ACE2 activity.